An efficient method for the synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitriles via a cascade Stetter―γ-ketonitrile cyclization reaction of aromatic aldehydes with acylidenemalononitriles, catalyzed by N-heterocyclic carbenes, has been developed. This procedure provides the corresponding products in moderate to high yields under mild conditions.

中文翻译：

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N-杂环卡宾催化级联Stetter-γ-酮腈环化反应高效合成2-氨基呋喃-3-腈

已开发出一种通过芳醛与亚丙基丙二腈的级联 Stetter-γ-酮腈环化反应合成 4,5-二取代 2-氨基呋喃-3-腈的有效方法，该反应由 N-杂环卡宾催化。该程序在温和条件下以中等至高产率提供相应的产品。