In this article a mild, simple, safe, and chemoselective synthesis and reduction of o-quinone methides to the corresponding 3-alkyl-2-hydroxy-1,4-naphthoquinones, compounds with interesting biological activity, mediated by the formic acid-water system is described. This new one-pot methodology was applied to the synthesis of lapachol and constitutes an efficient and inexpensive alternative for the preparation of this natural bioactive compound.

中文翻译：

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一种制备 3-Alkyl-2-hydroxy-1,4-naphthoquinones 的新方法：[nl] Lapachol 和 Phthiocol 的合成

在这篇文章中，通过甲酸-水介导，温和、简单、安全和化学选择性地合成邻醌甲基化物并将其还原为相应的 3-烷基-2-羟基-1,4-萘醌，这些化合物具有有趣的生物活性系统进行了说明。这种新的一锅法应用于拉帕酚的合成，构成了制备这种天然生物活性化合物的有效且廉价的替代方法。