The title compound (HBTU, 1) is a useful condensing agent, which has become in the past decade one of the most popular coupling reagents for in situ activation of peptide synthesis both in solid phase and in solution. [¹-5] The same benzotriazolyl derivative has also been successfully employed for esterifications, as for example in solid-phase nucleotide synthesis. [6] [7] In addition to its high reactivity, HBTU has also been shown to fulfill the very important requirement of minimizing racemization at adjacent sites. Sometimes, hydroxybenzotriazole (HOBt) is used together with HBTU as racemization suppressor. Thus, HBTU effectively performs condensation with high yields and minimal racemization, in simple experimental conditions and within short reaction times.

Figure 1

标题化合物（HBTU，1）是有用的缩合剂，在过去的十年中它已成为在固相和溶液中原位活化肽合成的最受欢迎的偶联剂之一。[ 1-5 ]相同的苯并三唑基衍生物也已成功地用于酯化反应，例如在固相核苷酸合成中。[ 6 ] [ 7除了高反应性外，HBTU还显示出满足最小化相邻位点消旋作用的非常重要的要求。有时，羟基苯并三唑（HOBt）与HBTU一起用作消旋抑制剂。因此，HBTU在简单的实验条件下和较短的反应时间内即可高效，高效地进行缩合反应。

图1