Four new honokiol derivatives, namely 8′,9′-dihydroxymagnaldehyde E (1), 8′,9′-dihydroxyhonokiol (2), erythro-7-O-methylhonokitriol (3), and threo-7-O-methylhonokitriol (4), together with seven known compounds, erythro-honokitriol (5), threo-honokitriol (6), magnaldehyde E (7), magnotriol B (8), magnaldehyde B (9), honokiol (10), and magnolol (11), were isolated from the stem bark of Magnolia officinalis. Their structures were established on the basis of extensive 1D and 2D NMR experiments as well as HR-MS. All isolates were evaluated for their in vitro activities against acetylcholinesterase and butyrylcholinesterase, the results demonstrated that compound 8 possessed potent inhibitory activity.

四个新的和厚朴酚的衍生物，即8'，9'- dihydroxymagnaldehyde E（1），8'，9'- dihydroxyhonokiol（2），赤-7- ø -methylhonokitriol（3）和苏式-7- ö -methylhonokitriol（4）以及七种已知化合物，赤型-厚朴三醇（5），苏-厚朴三醇（6），甲醛E（7），厚朴三醇B（8），厚朴醛B（9），厚朴酚（10）和厚朴酚（11） ，是从厚朴。它们的结构是根据广泛的1D和2D NMR实验以及HR-MS建立的。评价了所有分离物对乙酰胆碱酯酶和丁酰胆碱酯酶的体外活性，结果表明化合物8具有有效的抑制活性。