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Organotin(IV) 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioates: Synthesis, characterization and biological activities
Journal of Organometallic Chemistry ( IF 2.1 ) Pub Date : 2017-12-14 , DOI: 10.1016/j.jorganchem.2017.12.010
Farzana Shaheen , Muhammad Sirajuddin , Saqib Ali , Zia-ur-Rehman , Paul J. Dyson , Naseer Ali Shah , Muhammad Nawaz Tahir

A series of organotin(IV) derivatives R3SnL (1–3), R2SnLCl (4–6) and R2SnL2 (7–9) (where R = Me, Bu, Ph and L = 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate) were prepared from the reaction of 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate (L-salt) with the corresponding triorganotin(IV) chlorides and diorganotin(IV) dichlorides. All compounds were characterized by FT-IR, 1H, 13C and 119Sn NMR spectroscopy. Dimethylstannyl bis(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate) (7) was also characterized in the solid state by single crystal x-ray diffraction, showing a distorted octahedral geometry. The diorganotin(IV) derivatives have shown significant antibacterial and antifungal activity and good cytotoxic activity against ovarian cancer cells with IC50 values greater or comparable to that of cisplatin.



中文翻译:

有机锡(IV)4-(苯并[d] [1,3]二氧杂-5-基甲基)哌嗪-1-碳二硫代酸酯:合成,表征和生物活性

一系列有机锡(IV)衍生物R 3 SnL(1-3),R 2 SnLCl(4-6)和R 2 SnL 27-9)(其中R = Me,Bu,Ph和L = 4-(由4-(苯并[d] [1,3]二恶酚-5-基甲基)哌嗪-1-碳二硫酸酯反应制得(L-盐)与相应的三有机锡(IV)氯化物和二有机锡(IV)二氯化物。所有化合物均通过FT-IR,1 H,13 C和119 Sn NMR光谱进行表征。二甲基锡烷基双(4-(苯并[d] [1,3]二氧杂-5-基甲基)哌嗪-1-碳二硫代酸酯)(7)还通过单晶X射线衍射表征为固态,显示出扭曲的八面体几何形状。diorganotin(IV)衍生物对卵巢癌细胞显示出显着的抗菌和抗真菌活性,并具有良好的细胞毒性活性,其IC 50值大于或等于顺铂

更新日期:2017-12-14
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