By using a readily accessible, new and safe cyano-transfer reagent, 1-cyanato-4-nitrobenzene, the enantioselectivity of the direct electrophilic α-cyanation of 1-indanone-derived β-keto amides was greatly improved as a result of an enhanced double-hydrogen bonding. Thus, in the presence of cinchonine as the bifunctional organocatalyst, a series of α-cyano β-keto amides were produced in excellent yields (73–97%) and good to high enantioselectivities (75–91% ee) under mild reaction conditions.

中文翻译：

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1-氰基-4-硝基苯对β-酮酰胺的有机催化亲电α-氰化反应的改善

通过使用一种易于获得，安全的新型氰基转移试剂1-cyanato-4-硝基苯，由于增强了结构，大大提高了1-茚满酮衍生的β-酮酰胺的直接亲电子α-氰化的对映选择性。双氢键。因此，在金鸡宁作为双功能有机催化剂存在的情况下，在温和的反应条件下，可以以优异的收率（73-97％）和良好至高的对映选择性（75-91％ee）生产一系列α-氰基β-酮酰胺。