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Synthesis of 5-(trifluoromethyl)cyclohexane-1,2,3-trione (cVTC): new trifluoromethyl building block
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2016-10-13 , DOI: 10.1016/j.tetlet.2016.10.043
Chibuike D. Obi , Cosmas O. Okoro

A simple synthesis of 5-(trifluoromethyl)cyclohexane-1,2,3-trione is demonstrated in one step, by reacting 5-(trifluoromethyl)cyclohexane-1,3-dione with cerium(IV)ammonium nitrate (CAN) in methanol. The compound represents a highly functionalized oxygen-rich reactive intermediate for the synthesis of organic and heterocyclic compounds containing fluorine.



中文翻译:

5-(三氟甲基)环己烷-1,2,3-三酮(cVTC)的合成:新的三氟甲基构件

通过使5-(三氟甲基)环己烷-1,3-二酮与硝酸铈(IV)铵(CAN)在甲醇中反应,一步展示了5-(三氟甲基)环己烷-1,2,3-三酮的简单合成。该化合物代表高度官能化的富氧反应性中间体,用于合成含氟的有机和杂环化合物。

更新日期:2016-10-13
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