A practical and efficient synthesis of 3-trifluoromethyl functionalized indoles was successfully developed via Rh-catalyzed oxidative cross-coupling/annulations of readily available acetanilides with trifluoromethylated internal alkynes. Good yields and functional group tolerance as well as excellent regioselectivities were achieved under mild reaction conditions.

中文翻译：

---

通过Rh催化的乙苯胺与三氟甲基化炔烃的区域选择性氧化偶联反应合成3-三氟甲基吲哚

通过Rh催化的易得的乙酰苯胺与三氟甲基化的内部炔烃的氧化交叉偶联/环化反应，成功开发了一种实用且有效的3-三氟甲基官能化吲哚合成方法。在温和的反应条件下，可获得良好的收率和官能团耐受性，以及出色的区域选择性。