A simple two-step/one-pot and highly efficient strategy for the synthesis of negletein from naturally abundant and inexpensive baicalin has been developed. In this one-pot sequence, esterification of baicalin catalyzed by concentrated H₂SO₄ in methanol followed by the treatment with excess NaBH₄ afforded negletein in moderate yield. This method provides an additional approach for the synthesis of negletein.

中文翻译：

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从黄ical苷合成神经钙蛋白的便捷有效方法

已经开发了一种简单的两步一锅高效策略，可从天然丰富而廉价的黄ical苷合成神经钙蛋白。在该一锅法序列中，通过在甲醇中浓缩的H ₂ SO ₄催化黄in苷酯化，然后用过量的NaBH ₄处理，以中等收率得到了negletein。该方法提供了另一种合成神经钙蛋白的方法。