Advances in the use of poly (methyl methacrylate) (PMMA) have opened up a wide range of applications in the field of nanotechnology. The knowledge of the properties of PMMA has contributed a lot to the recent boosts in the synthesis, modification, and applications of the polymer. However, there is a need to condense these developments in the form of an article for better understanding and easy access. This review highlights the fundamental physical properties of PMMA, coupled with experimental evidence of its essential chemistry, such as solubility, hydrolysis, grafting, combustion reactions, reactions with amines, and thermal decomposition. The recent developments in the applications of PMMA in biomedical, optical, solar, sensors, battery electrolytes, nanotechnology, viscosity, pneumatic actuation, molecular separations, and polymer conductivity were also revealed.