A new class of benzazolyl pyrazoles were prepared from the simple substrates benzoxazol‐2‐thiol, benzothiazol‐2‐thiol, 1H‐benzimidazol‐2‐thiol and cinnamoyl chloride and tested for antimicrobial activity. The compounds 2‐(benzothiazol‐2‐ylthio)‐1‐(3‐(benzothiazol‐2‐ylthio)‐5‐phenyl‐1H‐pyrazol‐1‐yl)ethanone and 2‐(benzothiazol‐2‐ylamino)‐1‐(3‐(benzothiazol‐2‐ylthio)‐5‐phenyl‐1H‐pyrazol‐1‐yl)ethanone showed pronounced antibacterial activity against Klebsiella pneumoniae whereas 2‐(1H‐benzimidazol‐2‐ylthio)‐1‐(3‐(1H‐benzimidazol‐2‐ylthio)‐5‐phenyl‐1H‐pyrazol‐1‐yl)ethanone and 2‐(1H‐benzimidazol‐2‐ylamino)‐1‐(3‐(1H‐benzimidazol‐2‐ylthio)‐5‐phenyl‐1H‐pyrazol‐1‐yl) ethanone displayed excellent antifungal activity against Penicillium chrysogenum.

中文翻译：

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新型苯并唑基吡唑类化合物的合成及抑菌活性

用简单的底物苯并恶唑-2-硫醇，苯并噻唑-2-硫醇，1 H-苯并咪唑-2-硫醇和肉桂酰氯制备了一类新的苯并唑吡唑，并测试了其抗菌活性。化合物2-（苯并噻唑-2-基硫基）-1-（3-（苯并噻唑-2-基硫基）-5-苯基-1 H-吡唑-1-基）乙酮和2-（苯并噻唑-2-基氨基）- 1-（3-（苯并噻唑-2-基硫基）-5-苯基-1 H-吡唑-1-基）乙酮对肺炎克雷伯 菌具有明显的抗菌活性，而2-（1H-苯并咪唑-2-基硫基）-1-酮（3-（1 H-苯并咪唑-2-基硫基）-5-苯基-1H-吡唑-1-基）乙酮和2-（1 H-苯并咪唑-2-基氨基）-1-（3-（1H-苯并咪唑-2-基硫基）-5-苯基-1 H-吡唑基-1-基）乙酮对产 黄青霉具有优异的抗真菌活性。