In efforts to optimize a manufacturing process for an internal development compound, a clean, efficient approach to guanidine synthesis using chloroformamidine hydrochloride was identified. To investigate the general utility of this methodology towards electron‐deficient aromatic amines, a set of favorable conditions were developed from a series of screens, and the scope of the reaction was probed. The successful application of this chemistry to a variety of pyridines, anilines, and heterocyclic compounds highlights its use as an improved, alternative guanylation method for this often challenging set of aromatic amines.

中文翻译：

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盐酸氯甲am作为试剂从电子缺陷型芳香胺合成胍的应用

为了优化内部显影剂的制造工艺，已确定了使用盐酸氯甲am盐的一种清洁，有效的胍合成方法。为了研究这种方法对缺电子的芳族胺的一般用途，通过一系列筛选开发了一系列有利条件，并探查了反应范围。该化学方法成功应用于各种吡啶，苯胺和杂环化合物中，突显了其作为一种改良的，可替代的鸟苷酸化方法的用途，可用于这套通常具有挑战性的芳香族胺。