An Alzheimer's disease (AD) brain is featured with the oxidative and inflammatory microenvironment caused by overactivated microglia. In article number 1801586, Chen Jiang and co‐workers design a brain normalizing system to eliminate reactive oxygen species (ROS) and reeducate microglia from an early phase of AD. Through its efficient neuroprotection and microglia modulatory functions, decreased Aβ plaque burdens and improved cognition are achieved.

中文翻译：

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阿尔茨海默氏病：通过早期调节活化的小胶质细胞来改造阿尔茨海默氏病治疗的微环境胶束（Adv。Sci。4/2019）

小胶质细胞过度活化导致的氧化性和炎症性微环境是阿尔茨海默氏病（AD）脑的特征。Chen Jiang和他的同事在文章1801586中设计了一种大脑正常化系统，以消除活性氧（ROS）并在AD早期对小胶质细胞进行再教育。通过其有效的神经保护和小胶质细胞调节功能，可以减少Aβ斑块负担并提高认知能力。