Department of Chemical and Biomolecular Engineering; National University of Singapore; 4 Engineering Drive 4 Singapore 117585 Singapore
State Key Laboratory of Medicinal Chemical Biology; Key Laboratory of Bioactive Materials; Ministry of Education and College of Life Sciences; Nankai University; Tianjin 300071 China
Antibacterial Therapy: Metal–Organic‐Framework‐Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy (Adv. Mater. 18/2018)
In article number 1706831, Deling Kong, Bin Liu, and co‐workers report a new in vivo antibacterial strategy. With the help of a metal–organic framework, a functionalized amino acid, and photosensitizer nanoparticles with aggregation‐induced emission, bacteria hidden in the body can be specifically detected and killed via bioorthogonal reaction, followed by imaging‐guided photodynamic therapy. This in vivo metabolic labeling method may emerge as a promising alternative to antibiotics in antibacterial therapy.