A new chiral guanidine catalyst has been synthesized by the reaction of (R)-1-(1-phenylethyl)guanidine and 2,3-diphenylcycloprop-2-enone. The catalyst was evaluated for the Pictet-Spengler reaction in which tetrahydro-β-carbolines were obtained in good yields with up to 64% ee.

中文翻译：

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新型手性胍催化剂的合成及其在不对称Pictet-Spengler反应中的应用

通过（R）-1-（1-苯乙基）胍与2，3-二苯基环丙-2-烯酮的反应合成了一种新的手性胍催化剂。评价该催化剂的Pictet-Spengler反应，其中以高达64％ee的高收率获得四氢-β-咔啉。