Convenient Synthesis of Furo[3,2-b]quinolin-4(1H)-ones,Synlett

当前位置： X-MOL 学术 › Synlett › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Convenient Synthesis of Furo[3,2-b]quinolin-4(1H)-ones
Synlett ( IF 1.7 ) Pub Date : 2020-02-26 , DOI: 10.1055/s-0039-1691743
Veronika Králová ₁ , Miroslav Soural _{1,

2} , Radim Horák ₁ , Pavel Hradil ₁

Affiliation

In this work, we report the simple synthesis of furo[3,2-b]quinolin-4(1H)-ones from readily available 4-ethynyl-[1,3]dioxolo[4,5-c]quinolone as the key starting material. After Sonogashira (hetero)arylation, formation of the furoquinoline scaffold was accomplished using methanesulfonic acid and metal-free conditions. Although the cyclization was affected by the substitution of reaction intermediates, the method allowed the preparation of derivatives varying at the C3-position.

中文翻译：

Furo[3,2-b]quinolin-4(1H)-ones的便捷合成

在这项工作中，我们报告了从现成的 4-乙炔基-[1,3] 二氧杂环 [4,5-c] 喹诺酮中简单合成呋喃 [3,2-b] 喹啉-4(1H)-酮作为关键起始材料。Sonogashira（杂）芳基化后，使用甲磺酸和无金属条件完成呋喃喹啉支架的形成。尽管环化受反应中间体取代的影响，但该方法允许制备 C3 位变化的衍生物。

更新日期：2020-02-26

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南