An efficient, regioselective synthesis has been developed for the preparation of 5-(diphenylmethylene)-1H-pyrrol-2(5H)-ones from readily available 1H-pyrroles by sequential dibromination and selective organometallic bromine/lithium exchange followed by reaction with benzophenone. Comparison of various N-substituents was shown to demonstrate the high tolerance of the transformation to functional groups. The structures of the new products were determined by spectroscopic methods and confirmed by single-crystal X-ray diffraction measurement. In addition, theoretical study of the reaction mechanism and selective functionalization of the endocyclic double bond were also presented.

通过顺序二溴化和选择性有机金属溴/锂交换随后反应，已经开发了一种有效的区域选择性合成方法，用于从易于获得的1 H-吡咯中制备5-（二苯基亚甲基）-1 H-吡咯-2（5 H）-酮。与二苯甲酮。各种N-取代基的比较显示出对转化为官能团的高耐受性。通过光谱法确定新产物的结构，并通过单晶X射线衍射测量证实。此外，还对环内双键的反应机理和选择性官能化进行了理论研究。