Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy,Advanced Functional Materials

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Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-02-26 , DOI: 10.1002/adfm.201909391
Ge Gao ₁ , Yao‐Wen Jiang ₁ , Yuxin Guo ₁ , Hao‐Ran Jia ₁ , Xiaotong Cheng ₁ , Yu Deng ₁ , Xin‐Wang Yu ₁ , Ya‐Xuan Zhu ₁ , Hao‐Yue Guo ₂ , Wei Sun ₁ , Xiaoyang Liu ₁ , Jing Zhao ₃ , Shihe Yang ₄ , Zhi‐Wu Yu ₂ , Fatima Maria Sierra Raya ₁ , Gaolin Liang ₁ , Fu‐Gen Wu ₁

Affiliation

Compared with conventional tumor photothermal therapy (PTT), mild‐temperature PTT brings less damage to normal tissues, but also tumor thermoresistance, introduced by the overexpressed heat shock protein (HSP). A high dose of HSP inhibitor during mild‐temperature PTT might lead to toxic side effects. Glucose oxidase (GOx) consumes glucose, leading to adenosine triphosphate supply restriction and consequent HSP inhibition. Therefore, a combinational use of an HSP inhibitor and GOx not only enhances mild‐temperature PTT but also minimizes the toxicity of the inhibitor. However, a GOx and HSP inhibitor‐encapsulating nanostructure, designed for enhancing its mild‐temperature tumor PTT efficiency, has not been reported. Thermosensitive GOx/indocyanine green/gambogic acid (GA) liposomes (GOIGLs) are reported to enhance the efficiency of mild‐temperature PTT of tumors via synergistic inhibition of tumor HSP by the released GA and GOx, together with another enzyme‐enhanced phototherapy effect. In vitro and in vivo results indicate that this strategy of tumor starvation and phototherapy significantly enhances mild‐temperature tumor PTT efficiency. This strategy could inspire people to design more delicate platforms combining mild‐temperature PTT with other therapeutic methods for more efficient cancer treatment.

中文翻译：

酶介导的肿瘤饥饿和光疗增强了温和的光热疗法

与传统的肿瘤光热疗法（PTT）相比，温和的PTT对正常组织的伤害较小，但由过表达的热休克蛋白（HSP）引入的肿瘤耐热性较低。在温和的PTT期间高剂量的HSP抑制剂可能会导致毒副作用。葡萄糖氧化酶（GOx）消耗葡萄糖，导致三磷酸腺苷的供应受限，并因此抑制了HSP。因此，HSP抑制剂和GOx的组合使用不仅可以增强温和的PTT，而且可以将抑制剂的毒性降至最低。但是，尚未报道有设计用于提高其温和肿瘤PTT效率的GOx和HSP抑制剂包裹纳米结构。据报道，热敏感的GOx /吲哚菁绿/藤黄酸（GAIGLs）脂质体通过释放的GA和GOx协同抑制肿瘤HSP以及另一种酶增强的光疗作用来提高肿瘤的温和PTT效率。体外和体内结果表明，这种肿瘤饥饿和光疗策略可显着提高温和温度的肿瘤PTT效率。这种策略可能会激发人们设计更精致的平台，将温和的PTT与其他治疗方法结合起来，以更有效地治疗癌症。体外和体内结果表明，这种肿瘤饥饿和光疗策略可显着提高温和温度的肿瘤PTT效率。这种策略可能会激发人们设计更精致的平台，将温和的PTT与其他治疗方法结合起来，以更有效地治疗癌症。体外和体内结果表明，这种肿瘤饥饿和光疗策略可显着提高温和温度的肿瘤PTT效率。这种策略可能会激发人们设计更精致的平台，将温和的PTT与其他治疗方法结合起来，以更有效地治疗癌症。

更新日期：2020-04-21

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