Near‐Infrared‐Absorbing Diketopyrrolopyrrole‐Based Semiconducting Polymer Nanoparticles for Photothermal Therapy,Particle & Particle Systems Characterization

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Near‐Infrared‐Absorbing Diketopyrrolopyrrole‐Based Semiconducting Polymer Nanoparticles for Photothermal Therapy
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-02-13 , DOI: 10.1002/ppsc.201900433
Zuwu Wei ₁ , Bili Zhu ₁ , Yang Cai ₁ , Dan Yan ₂ , Yuheng Lou ₁ , Zhiyong Guo ₁ , Ping Deng ₁

Affiliation

Photothermal therapy, an excellent therapeutic approach, has received much attention in recent years. Herein, a novel diketopyrrolopyrrole polymer (DPP‐BDP) is prepared, which shows intense near‐infrared (NIR) optical absorption and admirable photothermal conversion efficacy. Impressively, after assembly into nanoparticles (DB‐FA), the as‐prepared conjugated polymer demonstrates a uniformly distributed size around 200 nm with remarkable NIR absorption at 808 nm. Additionally, it displays high biocompatibility and photostability. More interestingly, the obtained DB‐FA NPs are uptaken by cancer cells and present excellent anticancer in vitro and in vivo under 0.8 W cm⁻² or 1 W cm⁻² NIR laser irradiation, respectively. Hence, this work is expected to pave the way for using conjugated‐polymer nanoparticles as a powerful photothermal agents for anticancer applications.

中文翻译：

基于近红外吸收的基于二吡咯并吡咯基的半导体聚合物纳米粒子的光热疗法

光热疗法是一种出色的治疗方法，近年来受到了广泛关注。本文制备了一种新型的二酮吡咯并吡咯聚合物（DPP-BDP），该聚合物表现出强烈的近红外（NIR）光学吸收和令人赞叹的光热转换功效。令人印象深刻的是，组装成纳米颗粒（DB-FA）后，所制备的共轭聚合物在200 nm附近表现出均匀分布的尺寸，并在808 nm处具有显着的NIR吸收。此外，它还具有很高的生物相容性和光稳定性。更有趣的是，获得的DB-FA NP被癌细胞吸收，并且在0.8 W cm ^-2或1 W cm ^-2的条件下在体内和体外均表现出优异的抗癌性近红外激光照射。因此，这项工作有望为将共轭聚合物纳米粒子用作抗癌应用的强大光热剂铺平道路。

更新日期：2020-02-13

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