Tumour heterogeneity and the evolutionary trade-offs of cancer.,Nature Reviews Cancer

当前位置： X-MOL 学术 › Nat. Rev. Cancer › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Tumour heterogeneity and the evolutionary trade-offs of cancer.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2020-02-24 , DOI: 10.1038/s41568-020-0241-6
Jean Hausser _{1,

2} , Uri Alon ₃

Affiliation

Tumours vary in gene expression programmes and genetic alterations. Understanding this diversity and its biological meaning requires a theoretical framework, which could in turn guide the development of more accurate prognosis and therapy. Here, we review the theory of multi-task evolution of cancer, which is based upon the premise that tumours evolve in the host and face selection trade-offs between multiple biological functions. This theory can help identify the major biological tasks that cancer cells perform and the trade-offs between these tasks. It introduces the concept of specialist tumours, which focus on one task, and generalist tumours, which perform several tasks. Specialist tumours are suggested to be sensitive to therapy targeting their main task. Driver mutations tune gene expression towards specific tasks in a tissue-dependent manner and thus help to determine whether a tumour is specialist or generalist. We discuss potential applications of the theory of multi-task evolution to interpret the spatial organization of tumours and intratumour heterogeneity.

中文翻译：

肿瘤异质性与癌症的进化权衡。

肿瘤在基因表达程序和遗传改变中有所不同。了解这种多样性及其生物学意义需要一个理论框架，从而可以指导更准确的预后和治疗方法的发展。在此，我们回顾癌症的多任务进化理论，该理论基于肿瘤在宿主中进化以及多种生物学功能之间的面部选择权衡的前提。该理论可帮助确定癌细胞执行的主要生物学任务以及这些任务之间的权衡。它介绍了专注于一项任务的专科肿瘤和执行多项任务的通才肿瘤的概念。建议专业肿瘤对针对其主要任务的治疗敏感。驱动程序突变以组织依赖性方式针对特定任务调节基因表达，从而有助于确定肿瘤是专长还是普通。我们讨论了多任务进化理论在解释肿瘤的空间组织和肿瘤内异质性方面的潜在应用。

更新日期：2020-02-24

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南