Age-related pathological alterations of the vasculature have a critical role in morbidity and mortality of older adults. In epidemiological studies, age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. To develop novel therapeutic interventions for prevention of age-related vascular pathologies, it is crucial to understand the cellular and molecular mechanisms of vascular aging. In this review, shared molecular mechanisms of aging are considered in terms of their contribution to the pathogenesis of macrovascular and microvascular diseases associated with old age. The role of cellular senescence in development of vascular aging phenotypes is highlighted, and potential interventions to prevent senescence and to eliminate senescent cells for prevention of vascular pathologies are presented. The evidence supporting a role for interorgan communication and circulating progeronic and antigeronic factors in vascular aging is discussed.

中文翻译：

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血管老化机制，老年科学视角

血管系统的年龄相关病理改变在老年人的发病率和死亡率中具有关键作用。在流行病学研究中，年龄是最重要的心血管危险因素，它使传统危险因素的影响相形见绌。为了开发新的治疗干预措施来预防与年龄相关的血管病变，了解血管老化的细胞和分子机制至关重要。在这篇综述中，从衰老相关的大血管和微血管疾病发病机制的角度考虑了衰老的共同分子机制。强调了细胞衰老在血管老化表型发展中的作用，并提出了预防衰老和消除衰老细胞以预防血管病变的潜在干预措施。