A mild and efficient mono-selective bromination of 1,3-dicarbonyl compounds has been developed using lipophilic indole catalysts. Inexpensive and commercially available N-bromosuccinimide (NBS) was used as the brominating reagent. The selectivity was further enhanced when using stoichiometric amount of 3-bromoindole species. Mechanistic studies reveal that the indole catalyst has dual functions in the mono-bromination process.

中文翻译：

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亲脂吲哚介导的1,3-二羰基化合物的化学选择性α-单溴化

已经使用亲脂性吲哚催化剂开发了温和而有效的1,3-二羰基化合物的单选择溴化反应。廉价且可商购的N-溴琥珀酰亚胺（NBS）用作溴化试剂。当使用化学计量的3-溴吲哚类时，选择性进一步提高。机理研究表明，吲哚催化剂在单溴化过程中具有双重功能。