The fabrication of functional wound dressings to control skin bacterial infection is of vital importance. In this work, a silver (I) metal-organic framework Ag₂[HBTC][im] (1) and polylactic acid composite fibrous mat (1-PLA) with efficient antimicrobial capability was prepared via an electrospinning process. 1 possesses three-dimensional framework assembled from rod-shaped molecular building blocks which consist of Ag (I) ions, 1,3,5-benzenetricarboxylate (HBTC) and imidazole (im) ligand. The as-prepared 1-PLA shows unique broad-spectrum antibiosis potency against Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) and Mycobacterium smegmatis (M. smegmatis). Proteomic investigations enable to gain insight on the antimicrobial mechanism of 1-PLA composite indicating that the dissipation of proton motive force, destroying of energy metabolism, decreasing or losing of transport system may be associated with the antibacterial action. Furthermore, in vivo experiments indicate that the 1-PLA electrospun fibrous mat can significantly accelerate the healing rate of infection wounds in rats. This study demonstrated the electrospun fibrous mat with efficient on-demand antibacterial properties is promising for practical application in anti-infective therapy.

制备功能性伤口敷料以控制皮肤细菌感染至关重要。在这项工作中，通过静电纺丝工艺制备了具有有效抗菌能力的银（I）金属-有机骨架Ag ₂ [HBTC] [im]（1）和聚乳酸复合纤维毡（1- PLA）。图1具有由杆状分子构件组装而成的三维框架，所述杆状分子构件由Ag（I）离子，1,3,5-苯三甲酸（HBTC）和咪唑（im）配体组成。所制备的1 - PLA对大肠杆菌（E. coli），铜绿假单胞菌（Pseudomonas aeruginosa（E. coli））具有独特的广谱抗菌作用绿脓杆菌，金黄色葡萄球菌（S. aureus）和耻垢分枝杆菌（M. smegmatis）。蛋白质组学研究能够深入了解1- PLA复合材料的抗菌机制，表明质子原动力的散失，能量代谢的破坏，转运系统的减少或丧失可能与抗菌作用有关。此外，体内实验表明1-PLA电纺纤维毡可显着加快大鼠感染伤口的愈合速度。这项研究表明，具有高效按需抗菌特性的电纺纤维毡有望在抗感染治疗中得到实际应用。