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Degradation of the sporopollenin exine capsules (SECs) in human plasma
Applied Materials Today ( IF 7.2 ) Pub Date : 2020-02-12 , DOI: 10.1016/j.apmt.2020.100594
Teng-Fei Fan , Youngkyu Hwang , Michael G. Potroz , Kai-Lin Lau , Ee-Lin Tan , Mohammed Shahrudin Ibrahim , Eijiro Miyako , Nam-Joon Cho

The sporopollenin exine capsules (SECs) have recently attracted the attention of biological applications. The stability of SECs in human fluids is important issue to develop the controllable methods for the drug delivery system. Here, we analyzed the human plasma-triggered degradation of three species of SECs, i.e., camellia (Camellia sinensis L.), cattail (Typha angustifolia L.), and dandelion (Taraxacum officinale L.), regarding the physical and chemical aspects. The field emission scanning electron microscopy (FESEM) images showed no significant changes in the surface morphology of the SECs as increasing incubation time in human plasma, but we observed the increase of the rupture ratio by dynamic image particle analysis (DIPA). Also, Fourier-transform infrared spectroscopy (FTIR) combined with principal component analysis (PCA) addressed the chemical degradation in a species-specific manner. Specifically, the Osingle bondH groups of camellia SECs, Csingle bondOsingle bondC groups of cattail SECs, and Cdouble bondO groups of dandelion SECs showed significant changes.



中文翻译:

人血浆中孢粉蛋白外膜胶囊(SECs)的降解

孢粉素外膜胶囊(SEC)最近引起了生物学应用的注意。SEC在人体液体中的稳定性是开发药物输送系统可控方法的重要问题。在这里,我们分析了三种SEC中,人类血浆触发降解,山茶(茶树L.),香蒲(香蒲属),蒲公英(西洋蒲公英L.),关于物理和化学方面。场发射扫描电子显微镜(FESEM)图像显示,随着在人血浆中孵育时间的增加,SEC的表面形态没有明显变化,但是我们通过动态图像颗粒分析(DIPA)观察到破裂率的增加。同样,傅立叶变换红外光谱(FTIR)与主成分分析(PCA)相结合以特定物种的方式解决了化学降解的问题。具体来说,单键山茶花SEC的O H组,香蒲SEC的C 单键O 单键C组和双键蒲公英SEC的C O组表现出显着变化。

更新日期:2020-02-12
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