Legionella quorum sensing meets cyclic-di-GMP signaling.,Current Opinion in Microbiology

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Legionella quorum sensing meets cyclic-di-GMP signaling.
Current Opinion in Microbiology ( IF 5.9 ) Pub Date : 2020-02-08 , DOI: 10.1016/j.mib.2020.01.001
Ramon Hochstrasser ₁ , Hubert Hilbi ₁

Affiliation

Bacterial gene regulation occurs through complex networks, wherein linear systems respond to intracellular or extracellular cues and engage on vivid crosstalk. The ubiquitous water-borne bacterium Legionella pneumophila colonizes various distinct environmental niches ranging from biofilms to protozoa, and - as an 'accidental' pathogen - the human lung. Consequently, L. pneumophila gene regulation evolved to integrate a broad spectrum of different endogenous and exogenous signals. Endogenous signals produced and detected by L. pneumophila comprise the quorum sensing autoinducer LAI-1 (3-hydroxypentadecane-4-one) and c-di-GMP. As an exogenous cue, nitric oxide controls the c-di-GMP regulatory network of L. pneumophila. The Legionella quorum sensing (Lqs) system regulates virulence, motility and natural competence of L. pneumophila. The Lqs system is linked to c-di-GMP signaling through the pleiotropic transcription factor LvbR, which also regulates the architecture of L. pneumophila biofilms. In this review, we highlight recent insights into the crosstalk of Legionella quorum sensing and c-di-GMP signaling.

中文翻译：

军团菌定座感测满足循环di-GMP信号。

细菌基因调控通过复杂的网络进行，其中线性系统响应细胞内或细胞外线索并参与生动的串扰。无处不在的水传细菌嗜肺军团菌在各种不同的环境生态环境中定殖，范围从生物膜到原生动物，以及作为“偶然”病原体的人肺。因此，嗜肺乳杆菌的基因调控发展为整合了各种不同的内源性和外源性信号。肺炎链球菌产生和检测到的内源性信号包括群体感应自诱导物LAI-1（3-羟基十五烷-4-酮）和c-di-GMP。作为外源性线索，一氧化氮控制嗜肺乳杆菌的c-di-GMP调节网络。军团菌群体感应（Lqs）系统调节肺炎链球菌的毒力，运动性和自然能力。Lqs系统通过多效转录因子LvbR连接到c-di-GMP信号，该因子还调节嗜肺乳杆菌的生物膜结构。在这篇综述中，我们重点介绍军团菌群体感应和c-di-GMP信号传导的最新见解。

更新日期：2020-02-08

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