当前位置: X-MOL 学术Int. J. Obesity › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Potential role of the melanocortin signaling system interference in the excess weight gain associated to some antiretroviral drugs in people living with HIV.
International Journal of Obesity ( IF 4.2 ) Pub Date : 2020-02-20 , DOI: 10.1038/s41366-020-0551-5
Pere Domingo 1 , Francesc Villarroya 2 , Marta Giralt 2 , Joan Carles Domingo 2
Affiliation  

Exposure to some antiretroviral drugs, especially integrase strand transfer inhibitors (INsTI)-based combination antiretroviral therapy (cART) has been associated with weight gain in people living with HIV (PLWH) exceeding what would be a "return to health" phenomenon. Notwithstanding the fact that weight gain and obesity are multifactorial, the common epidemiological link in PLWH is INsTI-based cART. Here, we postulate that interference with the melanocortin system (MCS) functioning by INsTI plays an essential role in excess weight gain and obesity in PLWH, similar to disturbances caused by melanocortin receptor (MCR) mutations in the general population and by antipsychotic therapy in psychiatric patients.

中文翻译:

黑皮质素信号系统干扰 HIV 感染者与某些抗逆转录病毒药物相关的体重增加过多的潜在作用。

暴露于某些抗逆转录病毒药物,尤其是基于整合酶链转移抑制剂 (INsTI) 的联合抗逆转录病毒疗法 (cART) 与 HIV 感染者 (PLWH) 的体重增加有关,超过了“恢复健康”现象。尽管体重增加和肥胖是多因素的,但 PLWH 中常见的流行病学联系是基于 INsTI 的 cART。在这里,我们假设 INsTI 对黑皮质素系统 (MCS) 功能的干扰在 PLWH 的过度体重增加和肥胖中起着至关重要的作用,类似于一般人群中黑皮质素受体 (MCR) 突变和精神科抗精神病药物治疗引起的干扰。耐心。
更新日期:2020-02-20
down
wechat
bug