Kolbe Anodic Decarboxylation as a Green Way To Access 2-Pyrrolidinones.,Organic Letters

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Kolbe Anodic Decarboxylation as a Green Way To Access 2-Pyrrolidinones.
Organic Letters ( IF 4.9 ) Pub Date : 2020-02-18 , DOI: 10.1021/acs.orglett.0c00056
Mathilde Quertenmont ₁ , Iain Goodall ₂ , Kevin Lam ₂ , István Markó ₁ , Olivier Riant ₁

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Nootropic compounds are a group of pharmacologically active pyrrolidones. These molecules, which enhance cognition properties and possess a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. In this Article, we disclose an effective and environmentally friendly pyrrolidinone synthesis using electrosynthesis. The newly developed methodology includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical-radical cross-coupling.

中文翻译：

Kolbe阳极脱羧是获得2-吡咯烷酮的绿色途径。

促智化合物是一组具有药理活性的吡咯烷酮。这些增强认知特性并拥有广阔处方领域的分子，是制药行业特别感兴趣的合成靶标。在本文中，我们公开了一种利用电合成有效且环保的吡咯烷酮合成方法。新开发的方法包括Kolbe脱羧，然后进行分子内自由基环化和自由基-自由基交叉偶联。

更新日期：2020-02-19

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