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Self‐Mineralized Photothermal Bacteria Hybridizing with Mitochondria‐Targeted Metal–Organic Frameworks for Augmenting Photothermal Tumor Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-02-16 , DOI: 10.1002/adfm.201909806 Qi‐Wen Chen 1 , Xin‐Hua Liu 1 , Jin‐Xuan Fan 1 , Si‐Yuan Peng 1 , Jia‐Wei Wang 1 , Xia‐Nan Wang 1 , Cheng Zhang 1 , Chuan‐Jun Liu 1 , Xian‐Zheng Zhang 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-02-16 , DOI: 10.1002/adfm.201909806 Qi‐Wen Chen 1 , Xin‐Hua Liu 1 , Jin‐Xuan Fan 1 , Si‐Yuan Peng 1 , Jia‐Wei Wang 1 , Xia‐Nan Wang 1 , Cheng Zhang 1 , Chuan‐Jun Liu 1 , Xian‐Zheng Zhang 1
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A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1 (S. oneidensis MR‐1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It is found that PTB possesses superior photothermal property in near infrared (NIR) regions, as well as preferential tumor‐targeting capacity. Zeolitic imidazole frameworks‐90 (ZIF‐90) encapsulating photosensitizer methylene blue (MB) are hybridized on the surface of living PTB to further enhance PTT efficacy. MB‐encapsulated ZIF‐90 (ZIF‐90/MB) can selectively release MB at mitochondria and cause mitochondrial dysfunction by producing singlet oxygen (1O2) under light illumination. Mitochondrial dysfunction further contributes to adenosine triphosphate (ATP) synthesis inhibition and heat shock proteins (HSPs) down‐regulated expression. The PTB‐based therapeutic platform of PTB@ZIF‐90/MB demonstrated here will find great potential to overcome the challenges of tumor targeting and tumor heat tolerance in PTT.
中文翻译：
自矿化的光热细菌与线粒体靶向的金属有机框架杂交，以增强光热肿瘤治疗
通过使用兼性厌氧细菌Shewanella oneidensis MR-1（S.oneidensis MR-1）在其表面上生物矿化钯纳米颗粒（Pd NPs）而报道了一种光热细菌（PTB）用于肿瘤靶向的光热疗法（PTT）。。发现PTB在近红外（NIR）区域具有优异的光热特性，并具有优先的肿瘤靶向能力。封装光敏剂亚甲基蓝（MB）的沸石咪唑构架90（ZIF-90）在活性PTB的表面上杂交，以进一步增强PTT的功效。MB封装的ZIF-90（ZIF-90 / MB）可以通过释放单线态氧（1 O 2）选择性释放线粒体MB并引起线粒体功能障碍）。线粒体功能障碍进一步加剧了三磷酸腺苷（ATP）的合成抑制和热休克蛋白（HSPs）的表达下调。此处演示的基于PTB的PTB @ ZIF-90 / MB治疗平台将发现巨大的潜力，可以克服PTT中靶向肿瘤和耐热肿瘤的挑战。
更新日期：2020-04-06
中文翻译：
自矿化的光热细菌与线粒体靶向的金属有机框架杂交，以增强光热肿瘤治疗
通过使用兼性厌氧细菌Shewanella oneidensis MR-1（S.oneidensis MR-1）在其表面上生物矿化钯纳米颗粒（Pd NPs）而报道了一种光热细菌（PTB）用于肿瘤靶向的光热疗法（PTT）。。发现PTB在近红外（NIR）区域具有优异的光热特性，并具有优先的肿瘤靶向能力。封装光敏剂亚甲基蓝（MB）的沸石咪唑构架90（ZIF-90）在活性PTB的表面上杂交，以进一步增强PTT的功效。MB封装的ZIF-90（ZIF-90 / MB）可以通过释放单线态氧（1 O 2）选择性释放线粒体MB并引起线粒体功能障碍）。线粒体功能障碍进一步加剧了三磷酸腺苷（ATP）的合成抑制和热休克蛋白（HSPs）的表达下调。此处演示的基于PTB的PTB @ ZIF-90 / MB治疗平台将发现巨大的潜力，可以克服PTT中靶向肿瘤和耐热肿瘤的挑战。
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