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Camouflaging Nanoparticles with Brain Metastatic Tumor Cell Membranes: A New Strategy to Traverse Blood–Brain Barrier for Imaging and Therapy of Brain Tumors
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-02-16 , DOI: 10.1002/adfm.201909369 Caixia Wang 1 , Bo Wu 2 , Yuting Wu 1 , Xinyue Song 3 , Shusheng Zhang 3 , Zhihong Liu 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-02-16 , DOI: 10.1002/adfm.201909369 Caixia Wang 1 , Bo Wu 2 , Yuting Wu 1 , Xinyue Song 3 , Shusheng Zhang 3 , Zhihong Liu 1
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Glioblastoma multiforme is one of the most fatal intracranial tumors with no effective treatment. The drug concentration in tumor sites is usually insufficient to reach therapeutic levels, due to poor blood–brain‐barrier (BBB) permeability and short biological half‐life. Inspired by the proneness of those malignant tumors to brain metastasis, a brain metastatic tumor cell membrane‐coated nanocarrier with core–shell structure is constructed to cross BBB for imaging and photothermal therapy of early brain tumors. The cell membranes as the shell are extracted from different metastatic tumor cells, which endow the nanoparticles with BBB‐crossing ability and long circulation. Indocyanine green (ICG)‐loaded polymeric nanoparticle as the core allows fluorescence imaging and phototherapy of brain tumors. The as‐prepared biomimetic nanoparticles display superb BBB penetration and effective suppression of tumor growth. These findings suggest the biomimetic nanotechnology provides a new insight for the design of BBB‐crossing nanomaterials and is promising to treat brain diseases.
中文翻译：
用脑转移性肿瘤细胞膜伪装纳米颗粒：穿越血脑屏障成像和治疗脑肿瘤的新策略。
多形胶质母细胞瘤是最致命的颅内肿瘤之一，没有有效的治疗方法。由于血脑屏障（BBB）通透性差和生物学半衰期短，肿瘤部位的药物浓度通常不足以达到治疗水平。受这些恶性肿瘤易于发生脑转移的启发，构建了具有核-壳结构的脑转移性肿瘤细胞膜包被的纳米载体穿过BBB，用于早期脑肿瘤的成像和光热疗法。作为外壳的细胞膜是从不同的转移性肿瘤细胞中提取的，这赋予纳米颗粒具有BBB穿越能力和长循环性。负载吲哚菁绿（ICG）的聚合物纳米颗粒可以对脑部肿瘤进行荧光成像和光疗。所制备的仿生纳米颗粒显示出极好的BBB渗透性并有效抑制了肿瘤的生长。这些发现表明仿生纳米技术为穿越BBB的纳米材料的设计提供了新的见识，并有望用于治疗脑部疾病。
更新日期：2020-04-06
中文翻译：
用脑转移性肿瘤细胞膜伪装纳米颗粒：穿越血脑屏障成像和治疗脑肿瘤的新策略。
多形胶质母细胞瘤是最致命的颅内肿瘤之一，没有有效的治疗方法。由于血脑屏障（BBB）通透性差和生物学半衰期短，肿瘤部位的药物浓度通常不足以达到治疗水平。受这些恶性肿瘤易于发生脑转移的启发，构建了具有核-壳结构的脑转移性肿瘤细胞膜包被的纳米载体穿过BBB，用于早期脑肿瘤的成像和光热疗法。作为外壳的细胞膜是从不同的转移性肿瘤细胞中提取的，这赋予纳米颗粒具有BBB穿越能力和长循环性。负载吲哚菁绿（ICG）的聚合物纳米颗粒可以对脑部肿瘤进行荧光成像和光疗。所制备的仿生纳米颗粒显示出极好的BBB渗透性并有效抑制了肿瘤的生长。这些发现表明仿生纳米技术为穿越BBB的纳米材料的设计提供了新的见识，并有望用于治疗脑部疾病。
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