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HIV-1-induced inflammation shapes innate immunity and induces adaptive traits in NK cells
Nature Immunology ( IF 27.7 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41590-020-0615-7 Joanna Mikulak , Clara Di Vito , Domenico Mavilio
Nature Immunology ( IF 27.7 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41590-020-0615-7 Joanna Mikulak , Clara Di Vito , Domenico Mavilio
Chronic inflammation associated with HIV-1 infection disrupts the homeostasis of gut-resident innate lymphoid cells and induces the generation and expansion of adaptive NK cells expressing TCF7, a transcription factor that sustains their effector functions and memory-like properties.
中文翻译:
HIV-1引起的炎症影响先天免疫力并诱导NK细胞适应性状
与HIV-1感染相关的慢性炎症会破坏肠道固有的先天淋巴样细胞的稳态,并诱导表达TCF7的适应性NK细胞的生成和扩展,TCF7是一种转录因子,可维持其效应子功能和类似记忆的特性。
更新日期:2020-02-17
中文翻译:
HIV-1引起的炎症影响先天免疫力并诱导NK细胞适应性状
与HIV-1感染相关的慢性炎症会破坏肠道固有的先天淋巴样细胞的稳态,并诱导表达TCF7的适应性NK细胞的生成和扩展,TCF7是一种转录因子,可维持其效应子功能和类似记忆的特性。