Peak neutralizing and cross-neutralizing antibody levels to human papillomavirus types 6/16/18/31/33/45/52/58 induced by bivalent and quadrivalent HPV vaccines.,npj Vaccines

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Peak neutralizing and cross-neutralizing antibody levels to human papillomavirus types 6/16/18/31/33/45/52/58 induced by bivalent and quadrivalent HPV vaccines.
npj Vaccines ( IF 6.9 ) Pub Date : 2020-02-14 , DOI: 10.1038/s41541-020-0165-x
Filipe Colaço Mariz ₁ , Noemi Bender ₂ , Devasena Anantharaman ₃ , Partha Basu ₄ , Neerja Bhatla ₅ , Madhavan Radhakrisna Pillai ₃ , Priya R Prabhu ₃ , Rengaswamy Sankaranarayanan ₆ , Tiina Eriksson ₇ , Michael Pawlita ₂ , Kristina Prager ₂ , Peter Sehr ₈ , Tim Waterboer ₂ , Martin Müller ₁ , Matti Lehtinen _{2,

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Affiliation

We performed an independent comparison of neutralizing and cross-neutralizing antibody (ab) levels seven months after initiation of three-dose, six-month vaccination schedules with the bivalent and quadrivalent human papillomavirus (HPV) vaccines in adolescent Finnish and Indian females, respectively. We used a semi-automated Pseudovirion-Based Neutralization Assay and observed significantly higher HPV16/18 peak ab-levels in bivalent as compared to quadrivalent vaccine recipients. Bivalent vaccine induced cross-neutralizing HPV31/33/45/52/58 antibodies significantly more frequently and to higher levels than the quadrivalent vaccine. The correlation of bivalent vaccine-induced HPV45 ab-levels with HPV16/18 ab-levels was stronger than that of corresponding quadrivalent vaccine-induced ab-levels, suggesting a qualitatively different cross-reactive response. Our findings on the comparison of the immunogenicity of two HPV vaccine tested in two different populations indicate that further head-to-head studies are warranted.

中文翻译：

二价和四价 HPV 疫苗诱导的人乳头瘤病毒 6/16/18/31/33/45/52/58 型的中和和交叉中和抗体峰值水平。

我们分别对芬兰和印度青少年女性的二价和四价人乳头瘤病毒 (HPV) 疫苗开始为期 6 个月的三剂疫苗接种计划 7 个月后，对中和抗体 (ab) 水平和交叉中和抗体 (ab) 水平进行了独立比较。我们使用半自动的基于假病毒粒子的中和测定，观察到与四价疫苗接种者相比，二价疫苗接种者的 HPV16/18 峰值 ab 水平显着更高。与四价疫苗相比，二价疫苗诱导交叉中和 HPV31/33/45/52/58 抗体的频率和水平显着更高。二价疫苗诱导的 HPV45 ab 水平与 HPV16/18 ab 水平的相关性强于相应的四价疫苗诱导的 ab 水平，表明交叉反应反应有质的不同。我们对在两个不同人群中测试的两种 HPV 疫苗的免疫原性进行比较的结果表明，有必要进行进一步的头对头研究。

更新日期：2020-02-14

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