Rhodium-Catalyzed Diverse Arylation of 2,5-Dihydrofuran: Controllable Divergent Synthesis via Four Pathways,ACS Catalysis

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Rhodium-Catalyzed Diverse Arylation of 2,5-Dihydrofuran: Controllable Divergent Synthesis via Four Pathways
ACS Catalysis ( IF 11.3 ) Pub Date : 2020-02-14 , DOI: 10.1021/acscatal.0c00265
Junhao Xing ₁ , Wanjiang Zhu ₁ , Bihai Ye ₁ , Tao Lu ₁ , Tamio Hayashi ₂ , Xiaowei Dou ₁

Affiliation

The rhodium-catalyzed controllable diverse arylation of 2,5-dihydrofuran with arylboronic acids is reported. By fine-tuning of the reaction conditions, four different ring-opening or oxidative arylation pathways are controlled in the rhodium-catalyzed arylation of 2,5-dihydrofuran, granting selective access to 2-aryl or 3-aryl homoallylic alcohols and 3-aryl or 4-aryl-2,3-dihydrofurans. The catalytic asymmetric ring-opening arylation of 2,5-dihydrofuran was also realized. Four plausible reaction pathways were proposed, based on the experimental results.

中文翻译：

铑催化的2,5-二氢呋喃的多样化芳基化：可控制的通过四种途径的发散合成

报道了铑催化的2，5-二氢呋喃与芳基硼酸的可控制的各种芳基化。通过微调反应条件，在铑催化的2,5-二氢呋喃的芳基化反应中，可以控制四种不同的开环或氧化芳基化途径，从而可以选择性地使用2-芳基或3-芳基均烯丙基醇和3-芳基或4-芳基-2,3-二氢呋喃。还实现了2，5-二氢呋喃的催化不对称开环芳基化。根据实验结果，提出了四种可能的反应途径。

更新日期：2020-02-14

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