Rational design and latest advances of polysaccharide-based hydrogels for wound healing.,Biomaterials Science

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Rational design and latest advances of polysaccharide-based hydrogels for wound healing.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-02-13 , DOI: 10.1039/d0bm00055h
Hao Hu ₁ , Fu-Jian Xu ₂

Affiliation

Acute and chronic wounds cause severe physical trauma to patients and also bring an immense socio-economic burden. Hydrogels are considered to be effective wound dressings. Polysaccharides possessing distinctive properties such as biocompatibility, biodegradability, and nontoxicity are promising candidates to structure hydrogels for wound healing. Polysaccharide-based hydrogels can provide suitable moisture for the wound and act as a shield against bacteria. Adequate mechanical properties, degradability, and therapeutic agent controlled release of polysaccharide-based hydrogels have been already characterized for effective utilization. This review presented several crucial design considerations about hydrogels for wound healing, and the current state of polysaccharide (chitosan, alginate, hyaluronic acid, cellulose, dextran, and starch)-based hydrogels as wound dressings was also summarized. The commonly used crosslinking techniques, including physical, chemical, and enzymatic crosslinking, are discussed in detail. Finally, we outline the challenges and perspectives about the improvement of polysaccharide-based hydrogels.

中文翻译：

伤口愈合的多糖基水凝胶的合理设计和最新进展。

急性和慢性伤口会给患者带来严重的身体创伤，并带来巨大的社会经济负担。水凝胶被认为是有效的伤口敷料。具有诸如生物相容性，生物降解性和无毒性之类的独特特性的多糖是构造用于伤口愈合的水凝胶的有前途的候选者。基于多糖的水凝胶可以为伤口提供合适的水分，并起到抵抗细菌的作用。多糖基水凝胶的充分机械性能，可降解性和治疗剂控制释放已被表征为有效利用。这篇评论提出了有关伤口愈合用水凝胶以及多糖（壳聚糖，藻酸盐，透明质酸，纤维素，右旋糖酐，还总结了以淀粉和淀粉为基础的水凝胶作为伤口敷料。详细讨论了常用的交联技术，包括物理，化学和酶促交联。最后，我们概述了有关改进基于多糖的水凝胶的挑战和前景。

更新日期：2020-02-13

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