Inter-individual variation of the urinary steroid profiles in Swedish and Norwegian athletes.,Drug Testing and Analysis

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Inter-individual variation of the urinary steroid profiles in Swedish and Norwegian athletes.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-02-25 , DOI: 10.1002/dta.2778
Jenny Mullen ₁ , Lasse Vestli Baekken ₂ , Timo Törmäkangas ₃ , Lena Ekström ₁ , Magnus Ericsson _{1,

4} , Ingunn R Hullstein ₅ , Jenny J Schulze _{1,

6}

Affiliation

The steroidal module of the Athlete Biological Passport (ABP) aims to detect doping with endogenous steroids, e.g. testosterone (T), by longitudinally monitoring several biomarkers. These biomarkers are ratios combined into urinary concentrations of testosterone and metabolically related steroids. However, it is evident after 5 years of monitoring steroid passports that there are large variations in the steroid ratios complicating its interpretation. In this study, we used over 11000 urinary steroid profiles from Swedish and Norwegian athletes to determine both the inter‐ and intra‐individual variations of all steroids and ratios in the steroidal passport. Furthermore, we investigated if the inter‐individual variations could be associated with factors such as gender, type of sport, age, time of day, time of year, and if the urine was collected in or out of competition. We show that there are factors reported in today's doping tests that significantly affect the steroid profiles. The factors with the largest influence on the steroid profile were the type of sport classification that the athlete belonged to as well as whether the urine was collected in or out of competition. There were also significant differences based on what time of day and time of year the urine sample was collected. Whether these significant changes are relevant when longitudinally monitoring athletes in the steroidal module of the ABP should be evaluated further.

中文翻译：

瑞典和挪威运动员的尿类固醇特征之间的个体差异。

运动员生物护照（ABP）的类固醇模块旨在通过纵向监测几种生物标记物来检测内源性类固醇（例如睾丸激素（T））的掺杂。这些生物标志物是结合尿液中睾丸激素和代谢相关类固醇的比例。但是，在对类固醇护照进行5年的监测之后，很明显，类固醇比率存在很大差异，这使得其解释更加复杂。在这项研究中，我们使用了来自瑞典和挪威运动员的11000多种尿类固醇激素概况，以确定所有类固醇的个体间和个体内变异以及类固醇护照中的比率。此外，我们调查了个体差异是否与性别，运动类型，年龄，一天中的时间，一年中的时间，以及是否在比赛中或比赛中收集尿液。我们表明，当今的兴奋剂测试中报告了一些因素，这些因素会显着影响类固醇的概况。影响类固醇概况最大的因素是运动员所属的运动类别的类型，以及是否在比赛中或比赛中收集尿液。根据一天中的什么时间和一年中的时间，还存在显着差异。当在ABP的甾体模块中纵向监测运动员时，这些重大变化是否有意义，应该进一步评估。对类固醇概况影响最大的因素是运动员所属的运动类别的类型，以及是否在比赛中或比赛中收集尿液。根据一天中的什么时间和一年中的时间，还存在显着差异。当在ABP的甾体模块中纵向监测运动员时，这些重大变化是否有意义，应该进一步评估。影响类固醇概况最大的因素是运动员所属的运动类别的类型，以及是否在比赛中或比赛中收集尿液。根据一天中的什么时间和一年中的时间，还存在显着差异。当在ABP的甾体模块中纵向监测运动员时，这些重大变化是否有意义，应该进一步评估。

更新日期：2020-02-25

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