Multifunctional AuI -based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics.,Angewandte Chemie International Edition

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Multifunctional AuI -based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-03-05 , DOI: 10.1002/anie.202000048
Jing Zhang ₁ , Hang Zou ₂ , Jinping Lei ₃ , Benzhao He ₁ , Xuewen He ₁ , Herman H Y Sung ₁ , Ryan T K Kwok _{1,

4} , Jacky W Y Lam _{1,

4} , Lei Zheng ₂ , Ben Zhong Tang _{1,

4,

5}

Affiliation

Gold(I) N-heterocyclic carbene (AuI -NHC) complexes have emerged as potential anticancer agents owing to their high cytotoxicity and stability. Integration of their above unique functions with customized aggregation-induced emission (AIE) luminogens to achieve specific bioimaging and efficient theranostics to cancer is highly desirable but is rarely studied. Now, a series of novel AuI -NHC compounds were developed with AIE characteristics. A complex with a PPh3 ligand was selected out as it could achieve both prominent specific imaging of various cancer cells and efficient inhibition of their growth with negligible toxic effects on normal cells due to the targeting binding and strong inhibition towards thioredoxin reductase. This complex could also act as a powerful radiosensitizer to boost the anticancer efficacy with performance superior to that of popularly used auranofin. It holds great potential as a specific and effective theranostic drug in cancer diagnosis and precise therapy.

中文翻译：

多功能基于AuI的AIEgens：操纵分子结构并增强特定的癌细胞成像和治疗学。

金（I）N-杂环卡宾（AuI -NHC）复合物由于其高细胞毒性和稳定性而已成为潜在的抗癌剂。它们的上述独特功能与定制的聚集诱导发射（AIE）发光剂的集成，以实现对癌症的特定生物成像和有效的治疗学，是非常需要的，但很少进行研究。现在，已开发出具有AIE特性的一系列新型AuI -NHC化合物。选择具有PPh3配体的复合物，因为它既可以实现各种癌细胞的显着特异性成像，又可以有效抑制其生长，并且由于靶向结合和对硫氧还蛋白还原酶的强抑制作用，对正常细胞的毒性作用可忽略不计。该复合物还可以用作强大的放射增敏剂，以增强抗癌功效，其性能优于普遍使用的金诺芬。作为治疗癌症的特异性和有效治疗药物，它在癌症诊断和精确治疗方面具有巨大的潜力。

更新日期：2020-04-21

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