Thermo-responsive polymer nanocomposite based on poly (styrene-co-N-isopropylacrylamide) hybrid tungsten dioxide (WO2@PS-co-PNIPAM) was synthesized by a facile ultrasonic irradiation (Frequency; 20 kHz, power; 180 W, calorimetrically determined power; 5.73 W in the bath, and Type; probe) method in the presence of water as inisolv. The as-synthesized WO2@PS-co-PNIPAM modified glassy carbon electrode (WO2@PS-co-PNIPAM/GCE) was acting as a reversibly switched detection for the electrooxidation of metoprolol (MTP), with the thermal stimuli response of the PNIPAM. In below lower critical solution temperature (LCST), the PS-co-PNIPAM expanded to embed the electroactive sites of WO2, and the MTP could not proceed via the polymer to attain electronic transfer, indicating the "off" state. Rather, in above LCST, the PS-co-PNIPAM shrank to reveal electroactive sites and expand cyclic voltammetric background peak currents, the MTP was capable to undergo electro-oxidation reaction usually and produce the response current, indicating "on" state. Additionally, the proposed sensor had excellent sensitivity (2.21 µA µM-1 cm-2), wide dynamic range (0.05-306 µM), and a low limit of detection of 0.03 µM for MTP. Intriguingly, the fabricated sensor demonstrates the good selectivity towards the detection of MTP among the possible interfering compounds. Eventually, the WO2@PS-co-PNIPAM/GCE has been utilized in the analysis of MTP in human blood serum samples.

中文翻译：

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声化学合成新型热响应性聚合物和二氧化钨复合材料，用于温度控制的可逆“开-关”电化学检测β-Blocker美托洛尔。

通过简便的超声辐射（频率； 20 kHz，功率； 180 W，量热法确定的功率）合成了基于聚（苯乙烯-co-N-异丙基丙烯酰胺）杂化二氧化钨（WO2 @ PS-co-PNIPAM）的热敏性聚合物纳米复合材料；在浴中5.73 W，并在不存在水的情况下进行Type）探针法。合成后的WO2 @ PS-co-PNIPAM修饰玻碳电极（WO2 @ PS-co-PNIPAM / GCE）可逆转检测美托洛尔（MTP）的电氧化，并具有PNIPAM的热刺激响应。在低于较低的临界溶液温度（LCST）时，PS-co-PNIPAM膨胀以嵌入WO2的电活性位，而MTP无法通过聚合物进行电子转移，表明其处于“关闭”状态。相反，在LCST上方，PS-co-PNIPAM收缩以揭示电活性位并扩大循环伏安背景峰值电流，因此MTP通常能够进行电氧化反应并产生响应电流，从而指示“接通”状态。此外，所提出的传感器具有出色的灵敏度（2.21 µA µM-1 cm-2），宽动态范围（0.05-306 µM）以及对于MTP的0.03 µM检测下限。有趣的是，制成的传感器在可能的干扰化合物中显示出对MTP检测的良好选择性。最终，WO2 @ PS-co-PNIPAM / GCE已被用于分析人血清样品中的MTP。州。此外，所提出的传感器具有出色的灵敏度（2.21 µA µM-1 cm-2），宽动态范围（0.05-306 µM）以及对于MTP的0.03 µM检测下限。有趣的是，制成的传感器在可能的干扰化合物中显示出对MTP检测的良好选择性。最终，WO2 @ PS-co-PNIPAM / GCE已被用于分析人血清样品中的MTP。州。此外，所提出的传感器具有出色的灵敏度（2.21 µA µM-1 cm-2），宽动态范围（0.05-306 µM）以及对于MTP的0.03 µM检测下限。有趣的是，制成的传感器在可能的干扰化合物中显示出对MTP检测的良好选择性。最终，WO2 @ PS-co-PNIPAM / GCE已被用于分析人血清样品中的MTP。