Brain Differences Associated with Self-Injurious Thoughts and Behaviors: A Meta-Analysis of Neuroimaging Studies.,Scientific Reports

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Brain Differences Associated with Self-Injurious Thoughts and Behaviors: A Meta-Analysis of Neuroimaging Studies.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-02-12 , DOI: 10.1038/s41598-020-59490-6
Xieyining Huang ₁ , Kelly Rootes-Murdy _{1,

2} , Diana M Bastidas ₁ , Derek E Nee ₁ , Joseph C Franklin ₁

Affiliation

This meta-analysis aims to evaluate whether the extant literature justifies any definitive conclusions about whether and how SITBs may be associated with brain differences. A total of 77 papers (N = 4,903) published through January 1, 2019 that compared individuals with and without SITBs were included, resulting in 882 coordinates. A pooled meta-analysis assessing for general risk for SITBs indicated a lack of convergence on structural differences. When all types of control groups were considered, functional differences in the left posterior cingulate cortex (PCC), right amygdala, left hippocampus, and right thalamus were significant using multi-level kernel density analysis (pcorrected < 0.05) but nonsignificant using activation-likelihood estimation. These results suggest that a propensity for internally-oriented, emotional processing coupled with under-active pain processing could potentially underlie SITBs, but additional research is needed to test this possibility. Separate analyses for types of SITBs suggested that the brain differences associated with deliberate self-harm were consistent with the overall findings. Checkered moderator effects were detected. Overall, the meta-analytic evidence was not robust. More studies are needed to reach definitive conclusions about whether SITBs are associated with brain differences.

中文翻译：

与自我伤害的思想和行为相关的大脑差异：对神经影像研究的荟萃分析。

这项荟萃分析旨在评估现有文献是否证明关于SITB是否以及如何与脑部差异相关的任何明确结论。截至2019年1月1日，共发表77篇论文（N = 4,903），对具有和不具有SITB的个体进行比较，得出882个坐标。对SITB总体风险进行评估的汇总荟萃分析表明，在结构差异上缺乏收敛性。当考虑所有类型的对照组时，使用多级内核密度分析（校正后的<0.05）在左后扣带回皮层（PCC），右杏仁核，左海马和右丘脑中的功能差异是显着的（但使用激活似然法则无统计学意义）估计。这些结果表明，倾向于内部导向，情绪处理以及活动不足的疼痛处理可能是SITB的潜在原因，但是还需要进一步的研究来检验这种可能性。对SITB类型的单独分析表明，与故意自残相关的大脑差异与总体发现一致。检测到方格主持人效应。总体而言，荟萃分析证据不充分。需要更多的研究来得出关于SITB是否与大脑差异有关的明确结论。荟萃分析证据不充分。需要更多的研究来得出关于SITB是否与大脑差异有关的明确结论。荟萃分析证据不充分。需要更多的研究来得出关于SITB是否与大脑差异有关的明确结论。

更新日期：2020-02-12

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