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Magnetometer with nitrogen-vacancy center in a bulk diamond for detecting magnetic nanoparticles in biomedical applications.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-02-12 , DOI: 10.1038/s41598-020-59064-6 Akihiro Kuwahata 1 , Takahiro Kitaizumi 1 , Kota Saichi 1 , Takumi Sato 1 , Ryuji Igarashi 2 , Takeshi Ohshima 2 , Yuta Masuyama 2, 3 , Takayuki Iwasaki 3 , Mutsuko Hatano 3 , Fedor Jelezko 4 , Moriaki Kusakabe 5, 6 , Takashi Yatsui 1 , Masaki Sekino 1
Scientific Reports ( IF 3.8 ) Pub Date : 2020-02-12 , DOI: 10.1038/s41598-020-59064-6 Akihiro Kuwahata 1 , Takahiro Kitaizumi 1 , Kota Saichi 1 , Takumi Sato 1 , Ryuji Igarashi 2 , Takeshi Ohshima 2 , Yuta Masuyama 2, 3 , Takayuki Iwasaki 3 , Mutsuko Hatano 3 , Fedor Jelezko 4 , Moriaki Kusakabe 5, 6 , Takashi Yatsui 1 , Masaki Sekino 1
Affiliation
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We developed a novel magnetometer that employs negatively charged nitrogen-vacancy (NV-) centers in diamond, to detect the magnetic field generated by magnetic nanoparticles (MNPs) for biomedical applications. The compact probe system is integrated into a fiber-optics platform allowing for a compact design. To detect signals from the MNPs effectively, we demonstrated, for the first time, the application of an alternating current (AC) magnetic field generated by the excitation coil of several hundred microteslas for the magnetization of MNPs in diamond quantum sensing. In the lock-in detection system, the minimum detectable AC magnetic field (at a frequency of 1.025 kHz) was approximately 57.6 nT for one second measurement time. We were able to detect the micromolar concentration of MNPs at distances of a few millimeters. These results indicate that the magnetometer with the NV- centers can detect the tiny amounts of MNPs, thereby offering potential for future biomedical applications.
中文翻译：
大块钻石中具有氮空位中心的磁力计，用于检测生物医学应用中的磁性纳米粒子。
我们开发了一种新颖的磁力计，该磁力计在钻石中使用带负电荷的氮空位（NV-）中心，以检测生物医学应用中的磁性纳米颗粒（MNP）产生的磁场。紧凑的探头系统集成到光纤平台中，可实现紧凑的设计。为了有效地检测来自MNP的信号，我们首次展示了由数百微特斯拉的励磁线圈产生的交流（AC）磁场在金刚石量子传感中对MNP磁化的应用。在锁定检测系统中，在一秒钟的测量时间内，最小可检测到的交流磁场（频率为1.025 kHz）约为57.6 nT。我们能够在几毫米的距离处检测MNP的微摩尔浓度。
更新日期：2020-02-12
中文翻译：
大块钻石中具有氮空位中心的磁力计，用于检测生物医学应用中的磁性纳米粒子。
我们开发了一种新颖的磁力计，该磁力计在钻石中使用带负电荷的氮空位（NV-）中心，以检测生物医学应用中的磁性纳米颗粒（MNP）产生的磁场。紧凑的探头系统集成到光纤平台中，可实现紧凑的设计。为了有效地检测来自MNP的信号，我们首次展示了由数百微特斯拉的励磁线圈产生的交流（AC）磁场在金刚石量子传感中对MNP磁化的应用。在锁定检测系统中，在一秒钟的测量时间内，最小可检测到的交流磁场（频率为1.025 kHz）约为57.6 nT。我们能够在几毫米的距离处检测MNP的微摩尔浓度。
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