Recent Advances in Mechano-Responsive Hydrogels for Biomedical Applications,ACS Applied Polymer Materials

当前位置： X-MOL 学术 › ACS Appl. Polym. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Recent Advances in Mechano-Responsive Hydrogels for Biomedical Applications
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-02-19 , DOI: 10.1021/acsapm.0c00019
Jingsi Chen ₁ , Qiongyao Peng ₁ , Xuwen Peng ₁ , Linbo Han ₂ , Xiaogang Wang ₃ , Jianmei Wang ₃ , Hongbo Zeng ₁

Affiliation

Mechanical responsiveness is prevalent in biological systems and plays an essential role in many biomechanical processes. The past two decades have witnessed enormous effort devoted to the development of biomimetic mechano-responsive hydrogels which are capable of adapting their physical and chemical properties to external mechanical stimuli. Due to the combination of tissue similarity and mechano-responsive properties, this type of hydrogel offers great advantages for diverse biomedical applications. Strain-stiffening and self-healing hydrogels duplicate the physiological properties of biological tissues, serving as promising candidates for artificial tissues, tissue scaffolds, and wound dressings. The shear-thinning property provides the hydrogels injectability, and the regional delivery contributes to minimally invasive treatment. Mechanochromic hydrogels allow the direct visualization of mechanical stress, holding great promise in biosensing and diagnosing. This review highlights the most recent developments in mechano-responsive hydrogels with various applications in the biomedical field. Different types of mechano-responsive hydrogels are introduced with focus on their responsive mechanisms, design strategies, and in vitro/in vivo performances, providing useful insights into the understanding and future research directions of mechano-responsive hydrogels with applications in biomedical engineering.

中文翻译：

用于生物医学的机械响应水凝胶的最新进展

机械响应性在生物系统中很普遍，并且在许多生物力学过程中起着至关重要的作用。在过去的二十年中，目睹了巨大的努力致力于仿生机械响应水凝胶的开发，该凝胶能够使其物理和化学性质适应外部机械刺激。由于组织相似性和机械响应特性的结合，这种类型的水凝胶为各种生物医学应用提供了巨大的优势。应变增强和自修复水凝胶具有生物组织的生理特性，可作为人造组织，组织支架和伤口敷料的有希望的候选物。剪切稀化特性提供了水凝胶的可注射性，并且局部递送有助于微创治疗。机械致变色水凝胶可直接观察机械应力，在生物传感和诊断中具有广阔的前景。这篇综述着重介绍了机械响应型水凝胶的最新发展以及在生物医学领域的各种应用。介绍了不同类型的机械响应水凝胶，重点是它们的响应机制，设计策略和体外/体内性能，为了解机械响应水凝胶及其在生物医学工程中的应用和未来研究方向提供了有用的见识。

更新日期：2020-02-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南