Mussel-Inspired Naturally Derived Double-Network Hydrogels and Their Application in 3D Printing: From Soft, Injectable Bioadhesives to Mechanically Strong Hydrogels,ACS Biomaterials Science & Engineering

当前位置： X-MOL 学术 › ACS Biomater. Sci. Eng. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mussel-Inspired Naturally Derived Double-Network Hydrogels and Their Application in 3D Printing: From Soft, Injectable Bioadhesives to Mechanically Strong Hydrogels
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-02-21 , DOI: 10.1021/acsbiomaterials.9b01864
Zhongwei Guo _{1,

2} , Jingjing Xia ₂ , Shengli Mi ₂ , Wei Sun _{1,

2,

3,

4}

Affiliation

As promising candidates for tissue engineering, hydrogels possess great potential, especially in bioadhesives and load-bearing tissue scaffolds. However, a strategy for synthesizing hydrogels that could achieve the above requirements remains a challenge. Here, a mussel-inspired naturally derived double-network (DN) hydrogel composed of a special combination of two well-characterized natural polymers, hyaluronic acid and alginate, is presented. The key features are its two-step synthesis strategy, which generates injectable and adhesive properties in the first step and then transforms into a DN hydrogel with high mechanical strength and good resilient properties. Based on this strategy, the DN hydrogel could be tamed into a self-supporting three-dimensional (3D) printable bioink. As a rheological modifier, alginate was used to lubricate the covalent cross-linking hydrogels for better extrusion performance. The incorporation of alginate also enhanced the mechanical performance of the soft covalent network by forming reversible alginate–Ca²⁺ ionic cross-links, which interpenetrate through the outer water-retention scaffold with delicate weblike structures. In vitro cell culture data indicated that our bioink formulation and printing strategy are compatible with human umbilical vein endothelial cells (HUVECs).

中文翻译：

贻贝启发的天然衍生双网络水凝胶及其在3D打印中的应用：从柔软的可注射生物粘合剂到机械强度高的水凝胶

作为组织工程的有前途的候选者，水凝胶具有巨大的潜力，尤其是在生物粘合剂和承重组织支架中。然而，合成可以达到上述要求的水凝胶的策略仍然是一个挑战。在这里，提出了一种由贻贝启发的自然衍生双网络（DN）水凝胶，该凝胶由两种特性鲜明的天然聚合物透明质酸和藻酸盐特别组合而成。其主要特征是其两步合成策略，该策略首先产生可注射和粘合的特性，然后转变为具有高机械强度和良好回弹特性的DN水凝胶。基于此策略，可以将DN水凝胶驯服成可自我支撑的3D（3D）可打印生物墨水。作为流变改性剂，藻酸盐用于润滑共价交联水凝胶，以获得更好的挤出性能。通过形成可逆的藻酸盐-Ca，藻酸盐的掺入还增强了软共价网络的机械性能。²⁺离子交联键贯穿外部持水支架，形成纤巧的网状结构。体外细胞培养数据表明，我们的生物墨水配方和印刷策略与人脐静脉内皮细胞（HUVEC）兼容。

更新日期：2020-02-21

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南