互联网成瘾症中杏仁核连通性的改变。,Scientific Reports

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互联网成瘾症中杏仁核连通性的改变。
Scientific Reports ( IF 3.8 ) Pub Date : 2020-02-11 , DOI: 10.1038/s41598-020-59195-w
Hewei Cheng _{1,

2} , Jie Liu ₃

Affiliation

最近的研究表明杏仁核的结构和功能异常是由于与情感障碍相关的网络成瘾（IA）引起的。然而，杏仁核连通性的作用是负责情绪-认知相互作用的，在IA中是未知的。本研究旨在探讨IA中的杏仁核连接异常。使用基于种子的连通性分析检查了双边杏仁核的功能和结构连通性，还检查了通过杏仁核的白色物质道的结构完整性。另外，进行了相关分析以研究脑连接性与IA持续时间之间的关系。我们发现IA受试者杏仁核和背外侧前额叶皮层（DLPFC）之间的负功能连接性（FC）降低，并且杏仁核与早孕神经和枕上回（SOG）之间的负FC增加。IA受试者杏仁核和前扣带回皮层（ACC）之间的阳性FC减少，杏仁核和丘脑之间的FC阳性增加。左杏仁核和右DLPFC之间的FC与IA的持续时间显着相关。IA受试者中杏仁核和ACC之间的结构连接性和完整性也降低了。这些发现表明在IA受试者中杏仁核的连通性发生了改变。杏仁核-DLPFC的FC改变与IA的持续时间有关。左杏仁核和右DLPFC之间的FC与IA的持续时间显着相关。IA受试者中杏仁核和ACC之间的结构连接性和完整性也降低了。这些发现表明在IA受试者中杏仁核的连通性发生了改变。杏仁核-DLPFC的FC改变与IA的持续时间有关。左杏仁核和右DLPFC之间的FC与IA的持续时间显着相关。IA受试者中杏仁核和ACC之间的结构连接性和完整性也降低了。这些发现表明在IA受试者中杏仁核的连通性发生了改变。杏仁核-DLPFC的FC改变与IA的持续时间有关。

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Alterations in Amygdala Connectivity in Internet Addiction Disorder.

Recent studies have revealed structural and functional abnormalities in amygdala due to Internet addiction (IA) associated with emotional disturbance. However, the role of amygdala connectivity that is responsible for emotion-cognition interactions is largely unknown in IA. This study aims to explore the amygdala connectivity abnormalities in IA. The functional and structural connectivity of bilateral amygdala were examined using seed-based connectivity analysis, and the structural integrity on white mater tracts passing through amygdala was also examined. Additionally, a correlation analysis was performed to investigate the relationship between brain connectivity and duration of IA. We found that IA subjects had decreased negative functional connectivity (FC) between amygdala and dorsolateral prefrontal cortex (DLPFC), and had increased negative FC between amygdala and precuneus and superior occipital gyrus (SOG). While IA subjects had decreased positive FC between amygdala and anterior cingulate cortex (ACC), and had increased positive FC between amygdala and thalamus. The FC between left amygdala and right DLPFC had significant correlation with duration of IA. The structural connectivity and integrity between amygdala and ACC were also decreased in IA subjects. These findings indicate that the amygdala connectivity is altered in IA subjects. The altered FC of amygdala-DLPFC is associated with duration of IA.

更新日期：2020-02-11

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