Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents,Chemical Science

当前位置： X-MOL 学术 › Chem. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents
Chemical Science ( IF 7.6 ) Pub Date : 2020/02/05 , DOI: 10.1039/c9sc05510j
Hamilton Lee ₁ , Arezoo Shahrivarkevishahi ₁ , Jenica L Lumata ₁ , Michael A Luzuriaga ₁ , Laurel M Hagge ₁ , Candace E Benjamin ₁ , Olivia R Brohlin ₁ , Christopher R Parish ₂ , Hamid R Firouzi ₁ , Steven O Nielsen ₁ , Lloyd L Lumata ₂ , Jeremiah J Gassensmith _{1,

3}

Affiliation

Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further overcame the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.

中文翻译：

无金属磁共振成像造影剂的超分子和生物大分子增强

许多用于磁共振成像的造影剂都是基于钆的，但副作用限制了它们在某些患者中的使用。有机自由基造影剂（ORCA）是潜在的替代品，但在生理条件下会迅速减少，并且与单分子造影剂相比具有较低的弛豫度。在此，我们使用一种超分子策略，其中葫芦[8]尿素以纳摩尔亲和力与 ORCA 结合，并保护它们免受生物还原剂的影响，从而在体内产生稳定的自由基。我们通过将这种复合物缀合在源自烟草花叶病毒的自组装生物大分子的表面上，进一步克服了弱对比度。

更新日期：2020-02-26

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南