Total Synthesis of (−)-Batrachotoxinin A: A Local-Desymmetrization Approach,Journal of the American Chemical Society

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Total Synthesis of (−)-Batrachotoxinin A: A Local-Desymmetrization Approach
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-02-09 , DOI: 10.1021/jacs.9b12882
Yinliang Guo ₁ , Zhixian Guo ₁ , Jia-Tian Lu ₁ , Runting Fang ₁ , Si-Cong Chen ₁ , Tuoping Luo _{1,

2}

Affiliation

An enantioselective total synthesis of (-)-batrachotoxinin A is accomplished based on a key photoredox coupling reac-tion and the subsequent local-desymmetrization operation. After the expedient assembly of the highly-oxidized steroid skeleton, a delicate sequence of redox manipulations was carried out to deliver a late-stage intermediate in gram scale-and ultimately (-)-batrachotoxinin A in an efficient manner.

中文翻译：

(-)-Batrachotoxinin A 的全合成：一种局部去对称化方法

(-)-batrachotoxinin A 的对映选择性全合成是基于关键的光氧化还原偶联反应和随后的局部去对称化操作完成的。在高度氧化的类固醇骨架的方便组装之后，进行了一系列精细的氧化还原操作，以有效的方式提供克级规模的后期中间体 - 最终是 (-)-batrachotoxinin A。

更新日期：2020-02-09

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