Scalable Enantiomeric Separation of Dialkyl‐Arylphosphine Oxides Based on Host–Guest Complexation with TADDOL‐Derivatives, and their Recovery,European Journal of Organic Chemistry

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Scalable Enantiomeric Separation of Dialkyl‐Arylphosphine Oxides Based on Host–Guest Complexation with TADDOL‐Derivatives, and their Recovery
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-13 , DOI: 10.1002/ejoc.202000035
Bence Varga ₁ , Réka Herbay ₁ , György Székely _{2,

3} , Tamás Holczbauer ₄ , János Madarász ₅ , Béla Mátravölgyi ₁ , Elemér Fogassy ₁ , György Keglevich ₁ , Péter Bagi ₁

Affiliation

The enantioseparation of dialkyl‐arylphosphine oxides was elaborated, and five phosphine oxides were prepared with ee higher than 94 %. It was shown that these resolutions can be performed on gram scale, and can give both enantiomers of a phosphine oxide. It was demonstrated that organic solvent nanofiltration can serve as an alternative method of column chromatography for the recovery of the P‐oxide enantiomers and the resolving agents.

中文翻译：

基于主客体与TADDOL衍生物的络合反应的可扩展对映体分离二烷基芳基膦氧化物及其回收率

详细说明了二烷基-芳基膦氧化物的对映体分离，并制备了五种膦氧化物，其ee高于94％。已证明这些拆分可以以克为单位进行，并且可以给出氧化膦的两种对映异构体。结果表明，有机溶剂纳滤可以作为柱色谱的另一种方法，用于回收P-氧化物对映异构体和分离剂。

更新日期：2020-03-16

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