叶绿素衍生物的合成和自组装行为，用于比例光声信号优化。,Langmuir

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叶绿素衍生物的合成和自组装行为，用于比例光声信号优化。
Langmuir ( IF 3.7 ) Pub Date : 2020-02-07 , DOI: 10.1021/acs.langmuir.9b03652
Jin Zhou ₁ , Zi-Jun Gao ₂ , Jun-Quan Cai ₂ , Li-Li Li ₂ , Hao Wang ₂

Affiliation

自组装为研究人员提供了用于创建有序功能结构和复杂体系结构的强大工具。体内自组装的研究揭示了组装/聚集诱导的保留（AIR）效应和增强的靶向效应，可通过增强靶区域中的分子积累将其应用于有前途的生物医学应用中。这些独特的生物效应激发了研究人员在生物系统中构建自组装纳米材料的兴趣。尽管已经做出了很多努力，但是很少有关于程序集和功能之间关系的深入分析的报道。在这里，我们着眼于叶绿素衍生物组装及其光声信号的关系，并试图建立一种基于光声信号监测体内聚集效率的方法。设计并合成了三个富含精氨酸的肽-嘌呤分子。这些分子的组装能力和组装过程通过在混合溶剂中逐渐变化的极性的UV，荧光和CD光谱图像进行表征和监控，并通过TEM观察组装的形态。此外，系统地研究了分子的聚集比与比例光声信号之间的关系。我们希望揭示客观规律的基础研究将对将来优化光声检测窗口和组装分子设计的指导有用。混合溶剂中极性逐渐变化的荧光和CD光谱图像，并通过TEM观察组件的形态。此外，系统地研究了分子的聚集比与比例光声信号之间的关系。我们希望揭示客观规律的基础研究将对将来优化光声检测窗口和组装分子设计的指导有用。混合溶剂中极性逐渐变化的荧光和CD光谱图像，并通过TEM观察组件的形态。此外，系统地研究了分子的聚集比与比例光声信号之间的关系。我们希望揭示客观规律的基础研究将对将来优化光声检测窗口和组装分子设计的指导有用。

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Synthesis and Self-Assembly Behavior of Chlorophyll Derivatives for Ratiometric Photoacoustic Signal Optimization.

Self-assembly provides researchers powerful tools for creating ordered functional structures and complex architectures. Investigation of in vivo self-assembly reveals the assembly/aggregation-induced retention (AIR) effect and enhanced targeting effect, which can be applied to promising biomedical applications by enhancing molecular accumulation in the target region. These unique bioeffects inspire the interest of researchers in construction of self-assembled nanomaterials in biological systems. Although many efforts have been achieved, the in-depth analysis of the relationship between assemblies and functions is rarely reported. Here, we focus on the relationship of chlorophyll-derivative assemblies and their photoacoustic signals and attempt to establish a method for monitoring the aggregation efficiency in vivo based on photoacoustic signals. Three arginine-rich peptide-purpurin molecules were designed and synthesized. The assembled capabilities and assembly processes of these molecules were characterized and monitored by UV, fluorescence, and CD spectra images of gradually changing polarities in mixed solvents, and the morphologies of the assemblies were observed by TEM. Furthermore, the relationship between the aggregation ratios of the molecules and the ratiometric photoacoustic signals was systemically studied. We prospect that the fundamental research in revealing objective laws will be useful for future guidance in optimizing photoacoustic detection windows and assembled molecule design.

更新日期：2020-02-07

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