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Highly Efficient Production and Simultaneous Purification of Lactulose via Isomerization of Lactose through an Innovative Sustainable Anion-Extraction Process
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-02-18 , DOI: 10.1021/acssuschemeng.9b07779 Mingming Wang 1 , Fayin Ye 2 , He Wang 3 , Ruijin Yang 1 , Xiao Hua 1
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-02-18 , DOI: 10.1021/acssuschemeng.9b07779 Mingming Wang 1 , Fayin Ye 2 , He Wang 3 , Ruijin Yang 1 , Xiao Hua 1
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The traditional chemical isomerization of lactose into lactulose faces unfavorable thermodynamic limitations, significant side reactions, and high purification cost challenges. Herein, an efficient strategy for combining extraction-assisted isomerization and simultaneous purification of lactulose is presented. Under optimized conditions, 4-vinylphenylboronic acid (VPBA) favored the selective extraction of lactulose and up to 80% of lactulose can be extracted with a high selectivity (>95%). The extracted lactulose can be rapidly (<10 min) back-extracted into an acidic HCl solution as a concentrated lactulose stream (∼20 g/L). Lactulose purity can significantly be improved to 99.64% through a two-staged stripping process as a function of HCl contents. In situ removal of the newly formed lactulose catalyzed by Na2HPO4 + NaOH through selective extraction could significantly promote lactulose yield and minimize the formation of byproducts. The applied extraction-assisted isomerization strategy enabled the yield of lactulose up to ∼70% (batch-extraction model) and ∼85% (in situ extraction model), with the lowest yield of byproducts (<5%) ever found. Remarkably, the VPBA-dominated organic phase and the catalyst-containing aqueous phase could be easily regenerated and reused multiple times, well proving their feasibility in clean and sustainable industrial applications. This trial validates for the first time the use of the extraction-assisted strategy for an effective simultaneous isomerization and isolation of high-purity lactulose.
中文翻译：
通过创新的可持续阴离子提取工艺，通过乳糖的异构化，高效生产和同时纯化乳糖
乳糖传统的化学异构化成乳果糖面临着不利的热力学限制，显着的副反应和高纯化成本的挑战。在此，提出了一种结合提取辅助异构化和同时纯化乳果糖的有效策略。在优化条件下，有利于选择性提取乳果糖的4-乙烯基苯基硼酸（VPBA）可以以高选择性（> 95％）提取高达80％的乳果糖。可以将提取的乳果糖快速（<10分钟）反萃取为酸性HCl溶液（浓度约为20 g / L）到酸性HCl溶液中。通过两阶段的汽提过程，作为HCl含量的函数，乳果糖的纯度可以显着提高到99.64％。Na 2催化原位去除新形成的乳果糖通过选择性萃取得到的HPO 4 + NaOH可以显着提高乳果糖的收率并最大程度地减少副产物的形成。应用的提取辅助异构化策略可使乳果糖的收率高达70％（分批提取模型）和85％（原位提取模型），而副产物的收率最低（<5％）。值得注意的是，VPBA为主的有机相和含催化剂的水相可以轻松地再生和重复使用多次，充分证明了它们在清洁和可持续工业应用中的可行性。该试验首次验证了萃取辅助策略在有效同时异构化和分离高纯度乳果糖中的应用。
更新日期：2020-02-19
中文翻译：
通过创新的可持续阴离子提取工艺，通过乳糖的异构化，高效生产和同时纯化乳糖
乳糖传统的化学异构化成乳果糖面临着不利的热力学限制，显着的副反应和高纯化成本的挑战。在此，提出了一种结合提取辅助异构化和同时纯化乳果糖的有效策略。在优化条件下，有利于选择性提取乳果糖的4-乙烯基苯基硼酸（VPBA）可以以高选择性（> 95％）提取高达80％的乳果糖。可以将提取的乳果糖快速（<10分钟）反萃取为酸性HCl溶液（浓度约为20 g / L）到酸性HCl溶液中。通过两阶段的汽提过程，作为HCl含量的函数，乳果糖的纯度可以显着提高到99.64％。Na 2催化原位去除新形成的乳果糖通过选择性萃取得到的HPO 4 + NaOH可以显着提高乳果糖的收率并最大程度地减少副产物的形成。应用的提取辅助异构化策略可使乳果糖的收率高达70％（分批提取模型）和85％（原位提取模型），而副产物的收率最低（<5％）。值得注意的是，VPBA为主的有机相和含催化剂的水相可以轻松地再生和重复使用多次，充分证明了它们在清洁和可持续工业应用中的可行性。该试验首次验证了萃取辅助策略在有效同时异构化和分离高纯度乳果糖中的应用。
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