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Bacterial Detection and Elimination Using a Dual-Functional Porphyrin-Based Porous Organic Polymer with Peroxidase-Like and High Near-Infrared-Light-Enhanced Antibacterial Activity.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-02-05 , DOI: 10.1021/acsami.9b20102 Dekang Li 1 , Yishan Fang 2 , Xiaomei Zhang 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-02-05 , DOI: 10.1021/acsami.9b20102 Dekang Li 1 , Yishan Fang 2 , Xiaomei Zhang 1
Affiliation
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The efficient fabrication of multifunctional nanoplatforms for bacterial detection and elimination is of great importance in nanobiotechnology. A new porphyrin-based porous organic polymer, FePPOPBFPB, was synthesized via the reaction between pyrrole and 4-{2,2-bis[(4-formylphenoxy)methyl]-3-(4-formylphenoxy) propoxy} benzaldehyde (BFPB). The C-centric tetrahedral structure of BFPB promoted the formation of FePPOPBFPB with a 3D interconnected porous structure, high specific surface area, and plentiful surface catalytic active sites. The adjustable structural alkyl chain also enhanced the absorption capability of FePPOPBFPB in the long-wavelength visible and near-infrared regions (NIR). FePPOPBFPB exhibited excellent peroxidase-like activity toward a representative peroxidase substrate, 3,3',5,5'-tetramethylbenzidine (TMB) with H2O2. Utilizing these features, a rapid and visual detection of Staphylococcus aureus (S. aureus) based on FePPOPBFPB was established and exhibited high sensitivity and stability. Combining the catalysis with near-infrared-light (NIR) absorption, FePPOPBFPB can effectively catalyze the decomposition of biologically relevant concentrations of H2O2 to produce vast amounts of •OH radicals via the photo-Fenton reaction, which avoids the utilization of high toxic concentrations of H2O2. On the basis of these satisfactory features, FePPOPBFPB had a conspicuous bactericidal performance against S. aureus under NIR irradiation. To our knowledge, this is the first example of a porphyrin-based porous organic polymer antibacterial agent. The main reactive oxygen species (ROS) produced in this system and the possible antibacterial mechanism of FePPOPBFPB was also proposed through a series of experiments.
中文翻译：
使用具有过氧化物酶样和高近红外光增强抗菌活性的双功能基于卟啉的多孔有机聚合物进行细菌检测和消除。
用于细菌检测和消除的多功能纳米平台的有效制造在纳米生物技术中非常重要。通过吡咯与4- {2,2-双[（4-甲酰基苯氧基）甲基] -3-（4-甲酰基苯氧基）丙氧基}苯甲醛（BFPB）之间的反应合成了一种新的基于卟啉的多孔有机聚合物FePPOPBFPB。BFPB的以C为中心的四面体结构促进了FePPOPBFPB的形成，并具有3D互连的多孔结构，高比表面积和丰富的表面催化活性位。可调结构烷基链还增强了FePPOPBFPB在长波可见光和近红外区域（NIR）的吸收能力。FePPOPBFPB对具有代表性的过氧化物酶底物3,3'，5,5'-四甲基联苯胺（TMB）和H2O2表现出优异的过氧化物酶样活性。利用这些特征，建立了基于FePPOPBFPB的金黄色葡萄球菌（金黄色葡萄球菌）的快速视觉检测，并显示出高灵敏度和稳定性。FePPOPBFPB将催化与近红外（NIR）吸收相结合，可以有效地催化生物相关浓度的H2O2分解，通过光芬顿反应产生大量的•OH自由基，从而避免了高毒性浓度的H2O2的利用。过氧化氢 基于这些令人满意的特征，FePPOPBFPB在NIR照射下对金黄色葡萄球菌具有明显的杀菌性能。据我们所知，这是基于卟啉的多孔有机聚合物抗菌剂的第一个实例。
更新日期：2020-02-17
中文翻译：
使用具有过氧化物酶样和高近红外光增强抗菌活性的双功能基于卟啉的多孔有机聚合物进行细菌检测和消除。
用于细菌检测和消除的多功能纳米平台的有效制造在纳米生物技术中非常重要。通过吡咯与4- {2,2-双[（4-甲酰基苯氧基）甲基] -3-（4-甲酰基苯氧基）丙氧基}苯甲醛（BFPB）之间的反应合成了一种新的基于卟啉的多孔有机聚合物FePPOPBFPB。BFPB的以C为中心的四面体结构促进了FePPOPBFPB的形成，并具有3D互连的多孔结构，高比表面积和丰富的表面催化活性位。可调结构烷基链还增强了FePPOPBFPB在长波可见光和近红外区域（NIR）的吸收能力。FePPOPBFPB对具有代表性的过氧化物酶底物3,3'，5,5'-四甲基联苯胺（TMB）和H2O2表现出优异的过氧化物酶样活性。利用这些特征，建立了基于FePPOPBFPB的金黄色葡萄球菌（金黄色葡萄球菌）的快速视觉检测，并显示出高灵敏度和稳定性。FePPOPBFPB将催化与近红外（NIR）吸收相结合，可以有效地催化生物相关浓度的H2O2分解，通过光芬顿反应产生大量的•OH自由基，从而避免了高毒性浓度的H2O2的利用。过氧化氢 基于这些令人满意的特征，FePPOPBFPB在NIR照射下对金黄色葡萄球菌具有明显的杀菌性能。据我们所知，这是基于卟啉的多孔有机聚合物抗菌剂的第一个实例。
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