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MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product.
Organic Letters ( IF 4.9 ) Pub Date : 2020-02-04 , DOI: 10.1021/acs.orglett.9b04535 Fan Zhang 1 , Thomas P Wyche 2 , Yanlong Zhu 3, 4 , Doug R Braun 1 , Jia-Xuan Yan 1 , Shaurya Chanana 1 , Ying Ge 3, 4, 5 , Ilia A Guzei 5 , Marc G Chevrette 6, 7 , Cameron R Currie 7 , Michael G Thomas 7 , Scott R Rajski 1 , Tim S Bugni 1
Organic Letters ( IF 4.9 ) Pub Date : 2020-02-04 , DOI: 10.1021/acs.orglett.9b04535 Fan Zhang 1 , Thomas P Wyche 2 , Yanlong Zhu 3, 4 , Doug R Braun 1 , Jia-Xuan Yan 1 , Shaurya Chanana 1 , Ying Ge 3, 4, 5 , Ilia A Guzei 5 , Marc G Chevrette 6, 7 , Cameron R Currie 7 , Michael G Thomas 7 , Scott R Rajski 1 , Tim S Bugni 1
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Forazoline A is a structurally complex PKS-NRPS hybrid produced by marine-derived Actinomadura sp. During the course of studies highlighting the application of IFS analysis as a powerful tool for natural products analysis, we were alerted to an earlier misinterpretation with respect to forazoline A structure elucidation. In particular, IFS reveals that forazoline A contains a thioketone moiety rarely seen in secondary metabolites and, thus, constitutes an even more intriguing structure than originally thought.
中文翻译：
MS衍生的同位素精细结构揭示了甲azo啉A是一种含噻酮的海洋衍生天然产物。
Forazoline A是由海洋来源的Actinomadura sp。生产的结构复杂的PKS-NRPS杂种。在研究过程中，强调了IFS分析作为天然产物分析的有力工具的应用，我们被提醒注意有关甲唑啉A结构阐明的早期误解。特别是，IFS揭示了甲唑啉A含有在次级代谢产物中很少见的硫酮部分，因此，其结构比最初认为的还要有趣。
更新日期：2020-02-06
中文翻译：
MS衍生的同位素精细结构揭示了甲azo啉A是一种含噻酮的海洋衍生天然产物。
Forazoline A是由海洋来源的Actinomadura sp。生产的结构复杂的PKS-NRPS杂种。在研究过程中，强调了IFS分析作为天然产物分析的有力工具的应用，我们被提醒注意有关甲唑啉A结构阐明的早期误解。特别是，IFS揭示了甲唑啉A含有在次级代谢产物中很少见的硫酮部分，因此，其结构比最初认为的还要有趣。
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