Flower-like ceria (CeO₂) architectures consisting of well aligned nanosheets were first synthesized by a glycol solvothermal method. The size of CeO₂ architectures is about 5 μm in width and 10 μm in length, with the nanosheets thickness below 100 nm. Subsequently, the adsorbed Ag ions on the surface of CeO₂ were in situ reduced to form Ag nanoparticles (NPs), leading to the fabrication of Ag/CeO₂ hybrid architectures (HAs). The formed Ag NPs with sizes of 20–40 nm were uniformly loaded on the surface of the CeO₂ sheets. The antibacterial properties of Ag/CeO₂ HAs against Gram-negative E. coli and Gram-positive S. aureus were evaluated by minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and a filter paper inhibition zone method. The results demonstrated that Ag/CeO₂ HAs displayed excellent antibacterial activity toward S. aureus and E. coli, which were attributed to the synergistic antibacterial effect between Ag NPs and CeO₂ in HAs_. Here, CeO₂ nanoflowers as a new substrate could restrict Ag NPs aggregations and improve their antibacterial activities. Therefore, the resulted Ag/CeO₂ HAs would be considered as a promising antibacterial agent.

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首先通过乙二醇溶剂热法合成了由排列良好的纳米片组成的花状二氧化铈（CeO ₂）结构。CeO ₂结构的尺寸为宽度约5μm，长度约10μm，纳米片的厚度小于100 nm。随后，将CeO ₂表面吸附的Ag离子原位还原以形成Ag纳米颗粒（NPs），从而制造了Ag / CeO ₂混合体系结构（HAs）。形成的尺寸为20-40 nm的AgNP均匀地负载在CeO ₂薄片的表面上。Ag / CeO ₂ HAs对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌的抗菌性能通过最小抑菌浓度（MIC），最小杀菌浓度（MBC）和滤纸抑菌圈法对细菌进行评估。结果表明，Ag / CeO ₂ HAs对金黄色葡萄球菌和大肠杆菌具有优良的抗菌活性，这归因于Ag NPs和CeO ₂在HAs中的协同抗菌作用_。在这里，CeO ₂纳米花作为新的底物可以限制Ag NPs的聚集并提高其抗菌活性。因此，所得的Ag / CeO ₂ HA被认为是有前途的抗菌剂。

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