Abstract

In this article we reported preparation of 1-butyl-2-methylpipyridinium iodide ([BMPPY]I), as a novel ionic liquid (IL) through simple procedure. This newly prepared IL has been characterized by FT-IR, FESEM, EDX, TGA/DTG, ¹H NMR, ¹³C NMR, and Gc-mass techniques. The FESEM images revealed nano scale for the IL with the average diameter of 150–185 nm. Its efficacy examined for the synthesis of 6-hydroxy-6-(1H-indol-3-yl)indolo[2,1-b]quinazolin-12(6H)-ones via domino three-component reaction of isatin derivatives, isatoic anhydride, and indoles under solvent-free conditions at 100 °C. The results affirmed that ([BMPPY]I) possessed a dual catalytic/solvent role to promote this condensation. Non-flammability, thermal stability, non-toxicity and low cost of the IL that led to obtain pharmaceutically-active heterocycles though easy work-up procedure and short reaction times, are some highlighted features of this green protocol.

Graphical abstract

中文翻译：

---

1-丁基-2-甲基哌啶碘化物（[BMPPY] I）：用于合成6-羟基-6-（1 H-吲哚-3-基）吲哚[2,1-b]喹唑啉-12（的新型离子液体） 6 H）-ones在绿色无溶剂条件下

摘要

在本文中，我们通过简单的方法报道了一种新型离子液体（IL）的碘化1-丁基-2-甲基哌啶鎓（[BMPPY] I）的制备方法。通过FT-IR，FESEM，EDX，TGA / DTG，¹ H NMR，¹³ C NMR和Gc-mass技术对这种新制备的IL进行了表征。FESEM图像显示IL的纳米级，平均直径为150-185 nm。考察了其合成6-羟基-6-（1 H-吲哚-3-基）吲哚并[2,1 - b ]喹唑啉-12（6 H在100°C下于无溶剂条件下，通过Isatin衍生物，isatoic酸酐和吲哚的多米诺三组分反应进行反应）。结果证实（[BMPPY] I）具有双重催化/溶剂作用以促进这种缩合。IL的非易燃性，热稳定性，无毒性和低成本（通过简单的后处理步骤和较短的反应时间）获得了具有药理活性的杂环，是该绿色方案的一些突出特点。

图形概要